Phenotypes associated with this allele

• Allele Symbol: Tg(LRRK2)1Cjli
• Allele Name: transgene insertion 1, Chenjian Li
• Allele ID: MGI:3847810
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(LRRK2)1Cjli/0	FVB-Tg(LRRK2)1Cjli	MGI:3848698
tg2	Tg(LRRK2)1Cjli/0	FVB/N-Tg(LRRK2)1Cjli/J	MGI:5471774

Genotype
MGI:3848698

tg1

• Allelic Composition: Tg(LRRK2)1Cjli/0
• Genetic Background: FVB-Tg(LRRK2)1Cjli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:149135 )

N • mice develop normally and do not exhibit progressive motor behavioral deficits

Genotype
MGI:5471774

tg2

• Allelic Composition: Tg(LRRK2)1Cjli/0
• Genetic Background: FVB/N-Tg(LRRK2)1Cjli/J

cellular

abnormal autophagy ( J:194153 )

• chaperone-mediated autophagy is impaired in primary neuronal cultures as determined by the use of a photoactivatable fluorescent reporter to visualize movement from cytosol to lysosome

nervous system

alpha-synuclein inclusion body ( J:194153 )

• exogenous and endogenous alpha-synuclein is found associated to lysosomes and organized into irreversible oligomeric complexes in primary neuronal cultures

homeostasis/metabolism

abnormal autophagy ( J:194153 )

• chaperone-mediated autophagy is impaired in primary neuronal cultures as determined by the use of a photoactivatable fluorescent reporter to visualize movement from cytosol to lysosome