About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1Plt16
platelet 16
MGI:3847886
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l1Plt16/Bcl2l1Plt16 involves: BALB/c * C57BL/6 MGI:3847897
ht2
 		Bcl2l1Plt16/Bcl2l1+ involves: BALB/c * C57BL/6 MGI:3847898
ht3
 		Bcl2l1Plt20/Bcl2l1Plt16 involves: BALB/c * C57BL/6 MGI:3847900


Genotype
MGI:3847897
hm1
Allelic
Composition		 Bcl2l1Plt16/Bcl2l1Plt16
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:149205 )
• very few fetuses survive until birth




Genotype
MGI:3847898
ht2
Allelic
Composition		 Bcl2l1Plt16/Bcl2l1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are marginally elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (596x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)




Genotype
MGI:3847900
ht3
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1Plt16
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory