About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1Plt20
platelet 20
MGI:3847887
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l1Plt20/Bcl2l1Plt20 involves: BALB/c * C57BL/6 MGI:3847899
ht2
 		Bcl2l1Plt20/Bcl2l1+ involves: BALB/c * C57BL/6 MGI:3847901
ht3
 		Bcl2l1Plt20/Bcl2l1Plt16 involves: BALB/c * C57BL/6 MGI:3847900
ht4
 		Bcl2l1tm1Dlo/Bcl2l1Plt20 involves: BALB/c * C57BL/6 MGI:3847905
cx5
 		Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+ 		involves: 129 * BALB/c * C57BL/6 MGI:3847906


Genotype
MGI:3847899
hm1
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1Plt20
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
extramedullary hematopoiesis ( J:149205 )
• there is a slight increase in splenic erythropoiesis
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are significantly elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal
• splenectomy only partially restored platelet cell count
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced to under 12 hours compared to 57 hours for controls

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced to under 12 hours compared to 57 hours for controls




Genotype
MGI:3847901
ht2
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are marginally elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (598x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours)




Genotype
MGI:3847900
ht3
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1Plt16
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal




Genotype
MGI:3847905
ht4
Allelic
Composition		 Bcl2l1tm1Dlo/Bcl2l1Plt20
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal




Genotype
MGI:3847906
cx5
Allelic
Composition		 Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149205 )
• the low platelet numbers of Bcl2l1Plt20 heterozygotes do not occur in these mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory