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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1Plt20
platelet 20
MGI:3847887
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l1Plt20/Bcl2l1Plt20 involves: BALB/c * C57BL/6 MGI:3847899
ht2
 		Bcl2l1Plt20/Bcl2l1+ involves: BALB/c * C57BL/6 MGI:3847901
ht3
 		Bcl2l1Plt20/Bcl2l1Plt16 involves: BALB/c * C57BL/6 MGI:3847900
ht4
 		Bcl2l1tm1Dlo/Bcl2l1Plt20 involves: BALB/c * C57BL/6 MGI:3847905
cx5
 		Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+ 		involves: 129 * BALB/c * C57BL/6 MGI:3847906


Genotype
MGI:3847899
hm1
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1Plt20
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
extramedullary hematopoiesis ( J:149205 )
• there is a slight increase in splenic erythropoiesis
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are significantly elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal
• splenectomy only partially restored platelet cell count
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced to under 12 hours compared to 57 hours for controls

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced to under 12 hours compared to 57 hours for controls




Genotype
MGI:3847901
ht2
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are marginally elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (598x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours)




Genotype
MGI:3847900
ht3
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1Plt16
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal




Genotype
MGI:3847905
ht4
Allelic
Composition		 Bcl2l1tm1Dlo/Bcl2l1Plt20
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal




Genotype
MGI:3847906
cx5
Allelic
Composition		 Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149205 )
• the low platelet numbers of Bcl2l1Plt20 heterozygotes do not occur in these mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory