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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr0b2tm1.1Mjev
targeted mutation 1.1, Mark J Evans
MGI:3847927
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev involves: 129S/SvEvBrd * 129S4/SvJae MGI:3847956
cx2
Ldlrtm1Her/Ldlrtm1Her
Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3847958


Genotype
MGI:3847956
hm1
Allelic
Composition
Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic
Background
involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr0b2tm1.1Mjev mutation (0 available); any Nr0b2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal serum total cholesterol, triglyceride, alanine transaminase, and aspartate transaminase levels
• mice are resistant to decreased cholesterol levels when fed a cholesterol diet with cholic acid
• when fed an iodine-deficient diet compared to similarly treated wild-type mice
• when fed an iodine-deficient diet compared to similarly treated wild-type mice
• when fed a cholesterol with cholic acid diet compared to similarly treated wild-type mice
• when fed an iodine-deficient diet compared to similarly treated wild-type mice
• when fed a cholesterol diet with cholic acid compared to similarly treated wild-type mice




Genotype
MGI:3847958
cx2
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic
Background
involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
Nr0b2tm1.1Mjev mutation (0 available); any Nr0b2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice fed a Western diet fail to exhibit an increase in triglyceride and VLDL cholesterol levels unlike wild-type mice
• when fed a high fat diet
• mice fed a Western diet exhibit a reduced elevation in LDL cholesterol levels compared with similarly treated Ldlrtm1Her homozygotes





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory