Phenotypes associated with this allele

• Allele Symbol: Zbtb20^tm1.1Wpjz
• Allele Name: targeted mutation 1.1, Weiping J Zhang
• Allele ID: MGI:3848219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz	involves: 129S4/SvJae * C57BL/6	MGI:3848225

Genotype
MGI:3848225

hm1

• Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased liver glycogen level ( J:148992 )

• glycogen stores are almost completely absent in the liver compared to in wild-type mice

mortality/aging

lethality at weaning, incomplete penetrance ( J:148992 )

• around 3 weeks of age

premature death ( J:148992 )

• between 8 and 12 weeks with no mice surviving beyond 12 weeks

• however, lethality can be partially rescued by over-expression of Zbtb20

homeostasis/metabolism

abnormal blood homeostasis ( J:148992 )

• mice exhibit increased resistin serum levels compared with wild-type mice

increased blood urea nitrogen level ( J:148992 )

• at P17

increased circulating bilirubin level ( J:148992 )

• at P17

hypoglycemia ( J:148992 )

• in fed and fasted state

increased circulating glucagon level ( J:148992 )

decreased circulating insulin level ( J:148992 )

decreased circulating leptin level ( J:148992 )

increased circulating ketone body level ( J:148992 )

• mice exhibit increased beta-hydroxybutyrate serum levels compared with wild-type mice

increased circulating potassium level ( J:148992 )

• at P17

increased circulating alkaline phosphatase level ( J:148992 )

• at P17

increased circulating aspartate transaminase level ( J:148992 )

• at P17

improved glucose tolerance ( J:148992 )

abnormal glycogen homeostasis ( J:148992 )

• during a glucagons tolerance test, mice exhibit a reduction in the release of glucagons compared with similarly treated wild-type mice

decreased liver glycogen level ( J:148992 )

• glycogen stores are almost completely absent in the liver compared to in wild-type mice

increased insulin sensitivity ( J:148992 )

growth/size/body

decreased body weight ( J:148992 )

• at P10 to P15

postnatal growth retardation ( J:148992 )

• at P10 to P15, mice exhibit severe growth retardation and decreased axial growth compared with wild-type mice

nervous system

abnormal hippocampus development ( J:148992 )

• at P17