mortality/aging
• some mice die between E18.5 and P1
|
• 10-fold fewer mice than expected are present at weaning
• most mice die after birth
|
reproductive system
|
• despite normal germ cells development, one of 3 females fail to produce offspring and a second female only gave birth to one liter within 12 months
• female mice fail to produce offspring when mated to homozygous male mice despite normal male fertility when mated to wild-type mice
|
skeleton
• in 7 of 26 mice
|
• reduced in 24 of 26 mice
|
• in 24 of 26 mice rib ossification is reduced compared to in wild-type mice
|
respiratory system
• in embryos and newborns
|
• at E18.5, mice exhibit reduced alveolar space compared to in wild-type mice
|
atelectasis
(
J:149143
)
• at E18.5, lungs are poorly inflated unlike in wild-type mice
|
growth/size/body
• at E18.5
|
cellular
• female mice fail to produce offspring when mated to homozygous male mice despite normal male fertility when mated to wild-type mice
|