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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdx4tm1.1Jufu
targeted mutation 1.1, Junichi Fujii
MGI:3848347
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Prdx4tm1.1Jufu/Y involves: C57BL/6 MGI:3848358


Genotype
MGI:3848358
ot1
Allelic
Composition		 Prdx4tm1.1Jufu/Y
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdx4tm1.1Jufu mutation (0 available); any Prdx4 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:149074 )
• fewer than normal sperm are present
• however, surviving sperm are functionally normal
increased male germ cell apoptosis ( J:149074 )
• heat-treated spermatogenic cells exhibit increased apoptosis compared with similarly treated wild-type cells
• spermatogenic apoptosis is associated with increased oxidative damage compared to in wild-type cells

cellular
oligozoospermia ( J:149074 )
• fewer than normal sperm are present
• however, surviving sperm are functionally normal
increased male germ cell apoptosis ( J:149074 )
• heat-treated spermatogenic cells exhibit increased apoptosis compared with similarly treated wild-type cells
• spermatogenic apoptosis is associated with increased oxidative damage compared to in wild-type cells
oxidative stress ( J:149074 )
• spermatogenic apoptosis is associated with increased oxidative damage compared to in wild-type cells

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory