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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Irak2tm1Jth
targeted mutation 1, James A Thomas
MGI:3848359
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Irak2tm1Jth/Irak2tm1Jth involves: 129 * C57BL/6 MGI:3848360


Genotype
MGI:3848360
hm1
Allelic
Composition
Irak2tm1Jth/Irak2tm1Jth
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak2tm1Jth mutation (1 available); any Irak2 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 10% of LPS-treated mice die compared with 80% of similarly treated wild-type mice

immune system
• LPS-treated mice exhibit lower serum IL6 concentration compared with similarly treated wild-type mice
• LPS-treated mice exhibit lower serum TNF-alpha concentration compared with similarly treated wild-type mice
• LPS-treated mice exhibit lower serum CXCL1 (KC) concentration compared with similarly treated wild-type mice
• LPS- or R848-treated macrophages produce less chemokine (CXCL1) compared with similarly treated wild-type cells
• LPS- or R848-treated macrophages produce less cytokines IL6 compared with similarly treated wild-type cells
• LPS- or R848-treated macrophages produce less TNF-alpha compared with similarly treated wild-type cells
• only 10% of LPS-treated mice die compared with 80% of similarly treated wild-type mice
• LPS-treated mice exhibit lower serum cytokine (IL6 and TNF-alpha) and chemokine concentrations compared with similarly treated wild-type mice
• LPS- or R848-treated macrophages produce less cytokines (IL6 and TNF-alpha) and chemokine (CXCL1) compared with similarly treated wild-type cells

homeostasis/metabolism
• LPS-treated mice exhibit lower serum IL6 concentration compared with similarly treated wild-type mice
• LPS-treated mice exhibit lower serum TNF-alpha concentration compared with similarly treated wild-type mice
• LPS-treated mice exhibit lower serum CXCL1 (KC) concentration compared with similarly treated wild-type mice
• LPS- or R848-treated macrophages produce less chemokine (CXCL1) compared with similarly treated wild-type cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory