All Phenotypes Nxf2<tm1.2Jw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nxf2^tm1.2Jw Nxf3^tm1.2Jw/Y	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4950400
ot2	Nxf2^tm1.2Jw/Y	B6.Cg-Nxf2^tm1.2Jw	MGI:3848444
ot3	Nxf2^tm1.2Jw/Y	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:3848443

Allelic Composition	Nxf2^tm1.2Jw Nxf3^tm1.2Jw/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf2^tm1.2Jw mutation (0 available); any Nxf2 mutation (4 available)
Nxf3^tm1.2Jw mutation (0 available); any Nxf3 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:171521 )

decreased testis weight ( J:171521 )

endocrine/exocrine glands

decreased testis weight ( J:171521 )

cellular

oligozoospermia ( J:171521 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

early reproductive senescence ( J:149228 )

• 4 of 6 male mice sire 1 to 3 litters before becoming infertile unlike wild-type mice

reproductive system

reproductive system phenotype ( J:149228 )

N	• Background Sensitivity: on a congenic C57BL/6J background, meiosis progression is normal unlike on a mixed 129/Sv and C57BL/6 background

abnormal spermatogonia morphology ( J:149228 )

• mice exhibit an age-dependent loss of spermatogonia unlike wild-type mice

decreased male germ cell number ( J:149228 )

• at 9 months, 26% of seminiferous tubules lack germ cells unlike in wild-type mice

asthenozoospermia ( J:149228 )

• the percentage of motile sperm is decreased compared to in wild-type mice

small seminiferous tubules ( J:149228 )

• smaller in diameter

decreased testis weight ( J:149228 )

• 30% at 2 months

early reproductive senescence ( J:149228 )

• 4 of 6 male mice sire 1 to 3 litters before becoming infertile unlike wild-type mice

abnormal spermatogenesis ( J:149228 )

• impaired at 2.5 months of age

oligozoospermia ( J:149228 )

• epididymides contain half the number of sperm as in wild-type mice

abnormal spermatogonia proliferation ( J:149228 )

• reduced

decreased litter size ( J:149228 )

• from male mice

male infertility ( J:149228 )

• 2 of 6 males are sterile

reduced male fertility ( J:149228 )

• 4 of 6 male mice sire 1 to 3 litters before becoming infertile unlike wild-type mice

endocrine/exocrine glands

small seminiferous tubules ( J:149228 )

• smaller in diameter

decreased testis weight ( J:149228 )

• 30% at 2 months

cellular

abnormal spermatogonia morphology ( J:149228 )

• mice exhibit an age-dependent loss of spermatogonia unlike wild-type mice

decreased male germ cell number ( J:149228 )

• at 9 months, 26% of seminiferous tubules lack germ cells unlike in wild-type mice

oligozoospermia ( J:149228 )

• epididymides contain half the number of sperm as in wild-type mice

asthenozoospermia ( J:149228 )

• the percentage of motile sperm is decreased compared to in wild-type mice

abnormal spermatogonia proliferation ( J:149228 )

• reduced

Allelic Composition	Nxf2^tm1.2Jw/Y
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf2^tm1.2Jw mutation (0 available); any Nxf2 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:149228 )

N	• female mice exhibit normal fertility

abnormal male meiosis ( J:149228 )

• anaphase cells exhibit chromosome segregation is chaotic unlike in wild-type mice

• Background Sensitivity: on a mixed 129/Sv and C57BL/6 background, progression of meiosis is impaired unlike on a congenic C57BL/6J background

• however, the number of chromosome crossover sites is normal

arrest of male meiosis ( J:149228 )

• in males with small testes

meiotic nondisjunction during M1 phase ( J:149228 )

• in one third of mice

abnormal male germ cell apoptosis ( J:149228 )

• at Stage XII of spermatogenesis in one third of mice

decreased testis weight ( J:149228 )

• in 29% of mice

male infertility ( J:149228 )

• one third of male mice are infertile unlike wild-type mice

• however, remaining mice exhibit normal fertility

endocrine/exocrine glands

decreased testis weight ( J:149228 )

• in 29% of mice

cellular

abnormal male meiosis ( J:149228 )

• anaphase cells exhibit chromosome segregation is chaotic unlike in wild-type mice

• Background Sensitivity: on a mixed 129/Sv and C57BL/6 background, progression of meiosis is impaired unlike on a congenic C57BL/6J background

• however, the number of chromosome crossover sites is normal

arrest of male meiosis ( J:149228 )

• in males with small testes

meiotic nondisjunction during M1 phase ( J:149228 )

• in one third of mice

abnormal male germ cell apoptosis ( J:149228 )

• at Stage XII of spermatogenesis in one third of mice

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