Phenotypes associated with this allele

• Allele Symbol: Apc^tm1.1Rsmi
• Allele Name: targeted mutation 1.1, Ron Smits
• Allele ID: MGI:3848480
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apc^tm1.1Rsmi/Apc^+	involves: 129P2/OlaHsd	MGI:3848498
ht2	Apc^tm1.1Rsmi/Apc^+	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4456427

Genotype
MGI:3848498

ht1

• Allelic Composition: Apc^tm1.1Rsmi/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased gastrointestinal tumor incidence ( J:149225 )

• mice develop multiple intestinal tumors at an early age

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:149225 )

• mice develop multiple intestinal tumors at an early age

Genotype
MGI:4456427

ht2

• Allelic Composition: Apc^tm1.1Rsmi/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

growth/size/body

skin cyst ( J:159883 )

• very few cutaneous cysts are observed unlike in wild-type mice

mortality/aging

premature death ( J:159883 )

• primarily due to intestinal obstruction

neoplasm

increased gastrointestinal tumor incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased large intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased small intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased intestinal adenoma incidence ( J:159883 )

• polyp or flat adenoma

increased desmoid tumor incidence ( J:159883 )

• mice develop infrequent desmoid tumors

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased large intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased small intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased intestinal adenoma incidence ( J:159883 )

• polyp or flat adenoma

intestinal obstruction ( J:159883 )

hematopoietic system

anemia ( J:159883 )

• severe

integument

skin cyst ( J:159883 )

• very few cutaneous cysts are observed unlike in wild-type mice