mortality/aging
• die around E6 to E6.5
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• mice die during development (no time point given)
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Allele Symbol Allele Name Allele ID |
Itgb1tm5.1Ref targeted mutation 5.1, Reinhard Fassler MGI:3848527 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• die around E6 to E6.5
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• mice die during development (no time point given)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice are fertile unlike conditional null mice homozygous for Itgb1tm1Ref and hemizygous for Tg(KRT1-5-cre)5132Jlj
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• dermal fibrosis is accompanied by scattered melanin deposits
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• when cultured on a surface coated with collagen I and fibronectin, keratinocytes from 2.5 month old mice adhere but fail to spread and proliferate
• however, keratinocyte proliferation is similar to wild-type when cells are isolated from 6.5 month old mice
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• mildly affected
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• at P14, abnormally shaped hair follicles fail to grow as deeply into the subcutis compared to in control mice
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• loss of hair occurs between 6 and 12 months of age
• hair loss is delayed compared to conditional null mice homozygous for Itgb1tm1Ref and hemizygous for Tg(KRT1-5-cre)5132Jlj
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• coat is slightly thinner at 2 weeks of age compared to controls
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• at P14 about 60% of hair follicles are misshapen and arrested in morphogenesis
(J:148885)
• at P14 about 40% of hair follicles reach down to the muscle layer
(J:148885)
• at P14
(J:177979)
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• at P14 about 40% have severely abnormal and multilayered outer root sheaths
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• progressive hair loss is accompanied by development of dermal fibrosis with scattered melanin deposits
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• at P14 occasional small microblisters are seen at the dermal-epidermal junction
• however by 6.5 months of age almost no microblisters are seen in the epidermis of the back skin
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• dermal fibrosis is accompanied by scattered melanin deposits
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• when cultured on a surface coated with collagen I and fibronectin, keratinocytes from 2.5 month old mice adhere but fail to spread and proliferate
• however, keratinocyte proliferation is similar to wild-type when cells are isolated from 6.5 month old mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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