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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfxtm1.1Reiz
targeted mutation 1.1, Boris Reizis
MGI:3848796
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zfxtm1.1Reiz/Y
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ 		involves: 129/Sv * 129S6/SvEvTac MGI:3848801
cn2
 		Zfxtm1.1Reiz/Y
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:3848802
cn3
 		Zfxtm1.1Reiz/Zfxtm1.1Reiz
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:3848808
cn4
 		Zfxtm1.1Reiz/Y
Tg(Tek-cre)12Flv/0 		involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:3848804
cn5
 		Zfxtm1.1Reiz/Y
Tg(Mx1-cre)1Cgn/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3848805
cn6
 		Zfxtm1.1Reiz/Y
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3848803
cn7
 		Zfxtm1.1Reiz/Zfxtm1.1Reiz
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3848809


Genotype
MGI:3848801
cn1
Allelic
Composition		 Zfxtm1.1Reiz/Y
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal common lymphocyte progenitor cell morphology ( J:149654 )
• as early as 4 days after tamoxifen-induction
decreased hematopoietic stem cell number ( J:149654 )
• following tamoxifen treatment, the number of hematopoietic stem cell-containing LSK populations is decreased compared to in similarly treated wild-type mice
abnormal hematopoietic system physiology ( J:149654 )
• following tamoxifen treatment, maintenance of adult hematopoietic cells is abolished compared to in similarly treated wild-type mice




Genotype
MGI:3848802
cn2
Allelic
Composition		 Zfxtm1.1Reiz/Y
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:149654 )
• mice die shortly after birth




Genotype
MGI:3848808
cn3
Allelic
Composition		 Zfxtm1.1Reiz/Zfxtm1.1Reiz
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:149654 )
• mice die shortly after birth




Genotype
MGI:3848804
cn4
Allelic
Composition		 Zfxtm1.1Reiz/Y
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)12Flv mutation (1 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:149654 )
• mature T cells are decreased compared to in wild-type mice
decreased hematopoietic stem cell number ( J:149654 )
• mice exhibit a reduction in hematopoietic stem cells and specifically self-renewing long-term hematopoietic stem cells compared to in wild-type mice
abnormal hematopoietic system physiology ( J:149654 )
• maintenance of adult hematopoietic cells is abolished compared to in wild-type mice

immune system
decreased T cell number ( J:149654 )
• mature T cells are decreased compared to in wild-type mice




Genotype
MGI:3848805
cn5
Allelic
Composition		 Zfxtm1.1Reiz/Y
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation (7 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
impaired hematopoiesis ( J:149654 )
• pIpC-treated bone marrow cells fails to contribute to hematopoiesis in a competitively reconstituted bone marrow recipient unlike wild-type cells
abnormal common lymphocyte progenitor cell morphology ( J:149654 )
• following pIpC treatment, mice exhibit a reduction in lymphoid progenitor cells compared with wild-type mice
decreased lymphocyte cell number ( J:149654 )
• pIpC induction, lymphocyte are depleted and fail to regenerate unlike in similarly treated wild-type mice
decreased hematopoietic stem cell number ( J:149654 )
• 2 weeks after pIpC induction, the number of hematopoietic stem cell-containing LSK populations is decreased compared to in similarly treated wild-type mice
• following pIpC treatment, mice exhibit a reduction in hematopoietic stem cells, specifically self-renewing long-term and short-term hematopoietic stem cells and lymphoid progenitor cells, compared with wild-type mice
• however, proliferation of pIpC-treated erythroid-myeloid progenitor cells is normal
abnormal hematopoietic system physiology ( J:149654 )
• following pIpC treatment, hematopoietic stem cell apoptosis is increased compared to in similarly treated wild-type mice
• following pIpC treatment, maintenance of adult hematopoietic cells is abolished compared to in similarly treated wild-type mice

immune system
decreased lymphocyte cell number ( J:149654 )
• pIpC induction, lymphocyte are depleted and fail to regenerate unlike in similarly treated wild-type mice




Genotype
MGI:3848803
cn6
Allelic
Composition		 Zfxtm1.1Reiz/Y
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:149654 )
N
• mice survive into adulthood

nervous system
nervous system phenotype ( J:149654 )
N
• neurogenesis is normal




Genotype
MGI:3848809
cn7
Allelic
Composition		 Zfxtm1.1Reiz/Zfxtm1.1Reiz
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:149654 )
N
• mice survive into adulthood

nervous system
nervous system phenotype ( J:149654 )
N
• neurogenesis is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory