Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1-LDLR)93-4Reh
• Allele Name: transgene insertion 93-4, Robert E Hammer
• Allele ID: MGI:3848828
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Mt1-LDLR)93-4Reh/0	involves: C57BL/6 * SJL	MGI:3848834

Genotype
MGI:3848834

tg1

• Allelic Composition: Tg(Mt1-LDLR)93-4Reh/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:127519 )

• total plasma cholesterol concentration of CdSO₄-treated controls is 119 +/- 4.5 mg/dL whereas levels are 68 +/- 2.4 mg/dL in transgenic animals

decreased circulating LDL cholesterol level ( J:127519 )

• wild type mice treated with CdSO₄ have relatively high amounts of apo B in their plasma, while treated transgene-expressing mice have undetectable levels of the protein

• apo B completely disappears from plasma upon CdSO₄ treatment of transgenic animals, and levels of apo E are reduced by >90% compared to controls