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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc
targeted mutation 5, Andrew P McMahon
MGI:3848910
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Shhtm1Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster MGI:3848911
cn2
 		Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster MGI:3848912
cn3
 		Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster MGI:3848913


Genotype
MGI:3848911
cn1
Allelic
Composition		 Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Shhtm1Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Shhtm1Amc mutation (1 available); any Shh mutation (48 available)
Shhtm2Amc mutation (1 available); any Shh mutation (48 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:149478 )
• at P1, digits appear posteriorized comparing relative digit length and phalanx morphology with that of controls Shhtm1Amc/Shhtm2Amc Tg(Prrx1-cre)1Cjt mice
• however, mice have the same number of digits as in Shhtm1Amc/Shhtm2Amc Tg(Prrx1-cre)1Cjt mice




Genotype
MGI:3848912
cn2
Allelic
Composition		 Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb morphology ( J:149478 )
• less well-formed ectopic cartilaginous elements are observed in the anterior limb unlike in wild-type mice
polyphalangy ( J:149478 )
• the most anterior digit contains three phalanges instead of the normal two
polydactyly ( J:149478 )
• mice have 6 to 7 digits unlike in wild-type mice
• in some cases, the ectopic digit is more centrally located and consists of three phalangeal elements without an additional metacarpal element

skeleton
polyphalangy ( J:149478 )
• the most anterior digit contains three phalanges instead of the normal two




Genotype
MGI:3848913
cn3
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb development ( J:149478 )
• at P1, mice exhibit a more severe zeugopod phenotypes than in Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ Tg(Prrx1-cre)1Cjt mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory