About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pitx2-cre)1Ych
transgene insertion 1, YiPeng Chen
MGI:3848917
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hand2tm1Cse/Hand2tm1Cse
Tg(Pitx2-cre)1Ych/0 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3848963
cn2
 		Gsk3btm1.1Ypc/Gsk3btm1.1Ypc
Tg(Pitx2-cre)1Ych/0 		involves: 129S4/SvJaeSor * C57BL/6 MGI:4867291


Genotype
MGI:3848963
cn1
Allelic
Composition		 Hand2tm1Cse/Hand2tm1Cse
Tg(Pitx2-cre)1Ych/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Cse mutation (0 available); any Hand2 mutation (12 available)
Tg(Pitx2-cre)1Ych mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:149232 )
• a wide open cleft palate is observed
• no aberrant apoptosis is detected in palatal epithelium at E13.5
failure of palatal shelf elevation ( J:149232 )
• palatal shelves are not elevated at E16.5 (Fig. 4e)

digestive/alimentary system
cleft secondary palate ( J:149232 )
• a wide open cleft palate is observed
• no aberrant apoptosis is detected in palatal epithelium at E13.5
failure of palatal shelf elevation ( J:149232 )
• palatal shelves are not elevated at E16.5 (Fig. 4e)

growth/size/body
cleft secondary palate ( J:149232 )
• a wide open cleft palate is observed
• no aberrant apoptosis is detected in palatal epithelium at E13.5
failure of palatal shelf elevation ( J:149232 )
• palatal shelves are not elevated at E16.5 (Fig. 4e)




Genotype
MGI:4867291
cn2
Allelic
Composition		 Gsk3btm1.1Ypc/Gsk3btm1.1Ypc
Tg(Pitx2-cre)1Ych/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1.1Ypc mutation (0 available); any Gsk3b mutation (113 available)
Tg(Pitx2-cre)1Ych mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
palatal shelves fail to meet at midline ( J:166721 )
• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation
cleft secondary palate ( J:166721 )
• 11 of 14 mice show complete cleft of the secondary palate
failure of palatal shelf elevation ( J:166721 )
• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

digestive/alimentary system
palatal shelves fail to meet at midline ( J:166721 )
• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation
cleft secondary palate ( J:166721 )
• 11 of 14 mice show complete cleft of the secondary palate
failure of palatal shelf elevation ( J:166721 )
• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

growth/size/body
palatal shelves fail to meet at midline ( J:166721 )
• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation
cleft secondary palate ( J:166721 )
• 11 of 14 mice show complete cleft of the secondary palate
failure of palatal shelf elevation ( J:166721 )
• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory