Phenotypes associated with this allele

• Allele Symbol: hle
• Allele Name: head, lung, and eye
• Allele ID: MGI:3848924
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	hle/hle	involves: C3H/HeH * C57BL/6J	MGI:4948860

Genotype
MGI:4948860

hm1

• Allelic Composition: hle/hle
• Genetic Background: involves: C3H/HeH * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:171107 )

• no mice are observed postnatally and likely die around birth

respiratory system

lung hemorrhage ( J:171107 )

• at E13.5, mice exhibit blood pooling around the edges of the lobes unlike in wild-type mice

abnormal lung development ( J:171107 )

• at E13.5, lungs contain fewer epithelial branches compared with wild-type lungs indicating delayed development

• at E13.5, lung cells exhibit decreased proliferation and increased proliferation compared with wild-type mice

pulmonary hypoplasia ( J:171107 )

• at E13.5

nervous system

exencephaly ( J:171107 )

muscle

abnormal smooth muscle morphology ( J:171107 )

• at E18.5, proximal airwards exhibit reduced smooth muscle layer thickness compared to in wild-type mice

vision/eye

coloboma ( J:171107 )

cardiovascular system

lung hemorrhage ( J:171107 )

• at E13.5, mice exhibit blood pooling around the edges of the lobes unlike in wild-type mice