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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdx2tm1Khk
targeted mutation 1, Klaus H Kaestner
MGI:3848929
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdx2tm1Khk/Cdx2tm1Khk involves: C57BL/6 * SJL MGI:3848932
cn2
Cdx2tm1Khk/Cdx2tm1Khk
Tg(Foxa3-cre)1Khk/0
involves: C57BL/6 * DBA * SJL MGI:3848933


Genotype
MGI:3848932
hm1
Allelic
Composition
Cdx2tm1Khk/Cdx2tm1Khk
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2tm1Khk mutation (0 available); any Cdx2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:3848933
cn2
Allelic
Composition
Cdx2tm1Khk/Cdx2tm1Khk
Tg(Foxa3-cre)1Khk/0
Genetic
Background
involves: C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2tm1Khk mutation (0 available); any Cdx2 mutation (22 available)
Tg(Foxa3-cre)1Khk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
• at E14.5, mice exhibit a progressive defects in elongation compared with wild-type mice
• at E14.5, distal intestine contains a dilated gut lumen unlike in wild-type mice
• posterior gut region abnormalities are evident as early as E12.5
• terminal differentiation is severely impaired
• the intestine ends in an abnormal distal structure that terminates in a blind-sac
• mice exhibit intestinal obstruction unlike in wild-type mice
• at E16.5, mice exhibit a severe shortening of the intestine unlike in wild-type mice
• the posterior intestine is anteriorized
• terminal differentiation is severely impaired
• proximal and medial intestinal epithelia is less organized compared to in wild-type mice
• the cuboidal epithelia of the jejunum and ileum is replaced with a flattened epithelium
• duodenum epithelial cell proliferation is increased more than 20% compared to in wild-type mice
• however, apoptosis rates of duodenum epithelial cells are normal
• differentiation of gastric glandular epithelial cells cannot be detected
• posterior intestinal epithelial cells contain tonofilaments unlike in wild-type cells
• terminal differentiation is severely impaired
• the mutant ileum and cecum lack villi entirely
• no colon forms
• the duodenum contains villus-like epithelial foldings that are stunted and broadened compared to in wild-type mice
• duodenum epithelial cell proliferation is increased more than 20% compared to in wild-type mice
• however, apoptosis rates of duodenum epithelial cells are normal
• the duodenum becomes progressively distended and translucent likely due to fluid retention caused by distal obstruction
• by E18.5, the duodenum is dilated 5- to 7-fold compared to in wild-type mice
• at E16.5, mice exhibit villus hypoplasia
• at E18.5, reduced villus increases in severity from anterior to posterior
• the mutant ileum and cecum lack villi entirely

cellular
• terminal differentiation is severely impaired





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory