Phenotypes associated with this allele

• Allele Symbol: Srsf10^tm1Jalm
• Allele Name: targeted mutation 1, James L Manley
• Allele ID: MGI:3848950
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srsf10^tm1Jalm/Srsf10^tm1Jalm	involves: 129P2/OlaHsd * C57BL/6	MGI:3848955

Genotype
MGI:3848955

hm1

• Allelic Composition: Srsf10^tm1Jalm/Srsf10^tm1Jalm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149480 )

• remaining mice die within the first day of life

lethality throughout fetal growth and development, incomplete penetrance ( J:149480 )

• all but 5% of mice die around or before E15.5

cardiovascular system

abnormal myocardium layer morphology ( J:149480 )

• the myocardium is thin, undifferentiated, and disorganized compared to in wild-type mice

disorganized myocardium ( J:149480 )

thin myocardium ( J:149480 )

dilated heart right atrium ( J:149480 )

atrial septal defect ( J:149480 )

• at E14.5

complete atrioventricular septal defect ( J:149480 )

• at E16.5, mice exhibit a complete AVCD with a single atrioventricular junction

ventricular septal defect ( J:149480 )

• at E14.5

abnormal myocardial fiber physiology ( J:149480 )

• the incidence of spontaneous calcium ion sparks is increased compared to in wild-type mice

homeostasis/metabolism

edema ( J:149480 )

growth/size/body

fetal growth retardation ( J:149480 )

• beginning at E13.5 to E16.5

liver/biliary system

liver degeneration ( J:149480 )

muscle

abnormal myocardium layer morphology ( J:149480 )

• the myocardium is thin, undifferentiated, and disorganized compared to in wild-type mice

disorganized myocardium ( J:149480 )

thin myocardium ( J:149480 )