Phenotypes associated with this allele

• Allele Symbol: Osr2^{tm3(Osr1)Jian}
• Allele Name: targeted mutation 3, Rulang Jiang
• Allele ID: MGI:3849032
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Osr2^tm3(Osr1)Jian/Osr2^tm3(Osr1)Jian	involves: 129S1/Sv * C57BL/6J	MGI:3849036
ht2	Osr2^tm1Jian/Osr2^tm3(Osr1)Jian	involves: 129S1/Sv * C57BL/6J	MGI:3849037

Genotype
MGI:3849036

hm1

• Allelic Composition: Osr2^{tm3(Osr1)Jian}/Osr2^{tm3(Osr1)Jian}
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye development ( J:149458 )

• slight delay in eyelid outgrowth and a reduction in cell proliferation in the upper eyelid epithelium at E13.5

• at E15.5 eyelids have a rudimentary periderm leading edge that does not extend over the cornea

abnormal eyelid fusion ( J:149458 )

• at E18.5 the leading edges are still too far apart to complete fusion over the central region of the cornea

eyelids open at birth ( J:149458 )

• severity is reduced compared to mice homozygous for Osr2^tm1Jian

craniofacial

craniofacial phenotype ( J:149458 )

N • normal palate and tooth development unlike in mice homozygous for Osr2^tm1Jian

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:149458 )

N • normal tympanic ring morphology unlike in mice homozygous for Osr2^tm1Jian

Genotype
MGI:3849037

ht2

• Allelic Composition: Osr2^tm1Jian/Osr2^{tm3(Osr1)Jian}
• Genetic Background: involves: 129S1/Sv * C57BL/6J

vision/eye

eyelids open at birth ( J:149458 )

hearing/vestibular/ear

abnormal tympanic ring morphology ( J:149458 )

• slightly thickened but normal sized

craniofacial

craniofacial phenotype ( J:149458 )

N • normal palate and tooth development unlike in mice homozygous for Osr2^tm1Jian