All Phenotypes Etv5<tm1.2Xsun> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv5^tm1.2Xsun
targeted mutation 1.2, Xin Sun
MGI:3849049

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv5^tm1.2Xsun/Etv5^tm1.2Xsun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3849057
cn2	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL	MGI:3849054
cn3	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL	MGI:3849055
cx4	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.2Xsun/Etv5^tm1.2Xsun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3849056

Allelic Composition	Etv5^tm1.2Xsun/Etv5^tm1.2Xsun
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv5^tm1.2Xsun mutation (0 available); any Etv5 mutation (271 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:149477 )

• 12 of 17 mice exhibit preaxial polydactyly of often only one extra digit

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5^tm1.1Xsun mutation (2 available); any Etv5 mutation (271 available)
Etv5^tm1.2Xsun mutation (0 available); any Etv5 mutation (271 available)
Tg(T-cre)1Lwd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149477 )

• mice die shortly after birth due to internal organ defects

limbs/digits/tail

abnormal limb bud morphology ( J:149477 )

• limb buds exhibit reduced cell death compared to in wild-type mice

polyphalangy ( J:149477 )

• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice

preaxial polydactyly ( J:149477 )

• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal

• however, forelimbs are normal

embryo

abnormal limb bud morphology ( J:149477 )

• limb buds exhibit reduced cell death compared to in wild-type mice

skeleton

polyphalangy ( J:149477 )

• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice

Allelic Composition	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:149477 )

• in 6 of 8 mice

Allelic Composition	Etv4^tm1Arbr/Etv4^tm1Arbr Etv5^tm1.2Xsun/Etv5^tm1.2Xsun
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5^tm1.2Xsun mutation (0 available); any Etv5 mutation (271 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:149477 )

• mice die prior to limb bud initiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24