Phenotypes associated with this allele

• Allele Symbol: B4galt2^tm1Masn
• Allele Name: targeted mutation 1, Masahide Asano
• Allele ID: MGI:3849305
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B4galt2^tm1Masn/B4galt2^tm1Masn	B6.129P2-B4galt2^tm1Masn	MGI:3849317

Genotype
MGI:3849317

hm1

• Allelic Composition: B4galt2^tm1Masn/B4galt2^tm1Masn
• Genetic Background: B6.129P2-B4galt2^tm1Masn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced cortex and enlargement of the lateral ventricle in B4galt2^tm1Masn/B4galt2^tm1Masn mice

nervous system

abnormal cerebellar lobule formation ( J:149762 )

• compared to in heterozygous mice

decreased brain weight ( J:149762 )

• at 6 to 9 months, mice exhibit decreased brain weight compared with heterozygous mice

• however, brain weight at 2 months is normal

enlarged lateral ventricles ( J:149762 )

• at 8 months

thin cerebral cortex ( J:149762 )

• slightly at 6 to 9 months

decreased Purkinje cell number ( J:149762 )

• in the 4th and 5th cerebellar lobules

ectopic Purkinje cell ( J:149762 )

• mice exhibit ectopic Purkinje cells in the cerebellum with partially disturbed alignment unlike in heterozygous

behavior/neurological

abnormal spatial learning ( J:149762 )

• mice exhibit increased latency to escape in a Morris water maze compared with heterozygous mice

• however, mice exhibit normal learning and memory in a passive avoidance test

impaired coordination ( J:149762 )

• on a rotarod and balance beam

abnormal locomotor behavior ( J:149762 )

• in an open field test mice spend slightly more time in the center area compared with heterozygous mice

• however, mice exhibit normal activity speed and the number of rearing