Phenotypes associated with this allele

• Allele Symbol: Celsr3^tm1Mrc
• Allele Name: targeted mutation 1, Mario R Capecchi
• Allele ID: MGI:3849321
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Celsr3^tm1Mrc/Celsr3^tm1Mrc	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S6/SvEvTac * C57BL/6NCr)	MGI:3849330

Genotype
MGI:3849330

hm1

• Allelic Composition: Celsr3^tm1Mrc/Celsr3^tm1Mrc
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S6/SvEvTac * C57BL/6NCr)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149145 )

• mice die within hours of birth

nervous system

nervous system phenotype ( J:149145 )

N • the axonal pathfinding corridor appears normal

impaired neuronal migration ( J:149145 )

• at E17.5 and E18.5, late-born calretinin+ cells with migrating interneuron morphology accumulate at the corticostriatal boundary unlike in wild-type mice due to impaired tangential migration

• at E17.5 and E18.5, calretinin+ cells accumulate in the developing striatum unlike in wild-type mice due to impaired radial migration

• at E18.5, early- and late-born calbindin+ cell layering in the rostral to caudal and lateral to dorsal levels of the neocortex is defective due to impaired radial migration

• however, in vitro interneuron migration and differentiation are normal

abnormal globus pallidus morphology ( J:149145 )

• mice exhibit aberrant axonal fasciculation in the globus pallidus compared with wild-type mice

abnormal innervation ( J:149145 )

• mice exhibit aberrant axonal fasciculation in the globus pallidus and aberrant mesencephalic dopaminergic projections to the ventral surface of the telencephalon

abnormal embryonic/fetal subventricular zone morphology ( J:149145 )

• at E18.5 and E17.5, mice exhibit fewer calretinin+ cells in the neocortical subventricular zone compared with wild-type mice

cellular

impaired neuronal migration ( J:149145 )

• at E17.5 and E18.5, late-born calretinin+ cells with migrating interneuron morphology accumulate at the corticostriatal boundary unlike in wild-type mice due to impaired tangential migration

• at E17.5 and E18.5, calretinin+ cells accumulate in the developing striatum unlike in wild-type mice due to impaired radial migration

• at E18.5, early- and late-born calbindin+ cell layering in the rostral to caudal and lateral to dorsal levels of the neocortex is defective due to impaired radial migration

• however, in vitro interneuron migration and differentiation are normal