Phenotypes associated with this allele

• Allele Symbol: Kmt2a^tm1.1Brad
• Allele Name: targeted mutation 1.1, Hugh JM Brady
• Allele ID: MGI:3849323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2a^tm1.1Brad/Kmt2a^tm1.1Brad	involves: 129S4/SvJae * C57BL/6	MGI:3849328

Genotype
MGI:3849328

hm1

• Allelic Composition: Kmt2a^tm1.1Brad/Kmt2a^tm1.1Brad
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:149811 )

• homozygous embryos die between E12.5-E16.5

hematopoietic system

decreased common myeloid progenitor cell number ( J:149811 )

• there is a about a 5-fold reduction in myeloid CFU isolated from E13.5 fetal livers

• relative proportions of the different myeloid colony types are normal

abnormal hematopoietic stem cell morphology ( J:149811 )

• in E13.5 fetal livers, there is a 4-fold reduction in long term HSC numbers and a 3-fold reduction in the short term HSC numbers

• the majority of the cells missing are in the G0 phase suggesting a selective loss of quiescent HSC

decreased hematopoietic stem cell number ( J:149811 )

• in E13.5 fetal livers, there is a 4-fold reduction in long term HSC numbers and a 3-fold reduction in the short term HSC numbers

• the majority of the cells missing are in the G0 phase suggesting a selective loss of quiescent HSC

liver/biliary system

abnormal liver development ( J:149811 )

• fetal liver cellularity is reduced 2.5-fold at both E13.5 and E14.5 compared to controls