All Phenotypes Mfng<tm1Seco> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mfng^tm1Seco
targeted mutation 1, Susan E Cole
MGI:3849429

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfng^tm1Seco/Mfng^tm1Seco	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:3849430
cx2	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ	MGI:3849431
cx3	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco Rfng^tm1Tfv/Rfng^tm1Tfv	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ	MGI:3849432

Allelic Composition	Mfng^tm1Seco/Mfng^tm1Seco
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfng^tm1Seco mutation (1 available); any Mfng mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:149312 )

• viable and fertile with no gross abnormalities

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfng^tm1Seco mutation (1 available); any Mfng mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:149312 )

• fewer than expected are found at weaning however survivors are viable and fertile

postnatal lethality, incomplete penetrance ( J:149312 )

• fewer than expected are found at weaning

• reduction in numbers found at weaning is not greater than that of Lfng^tm1Rjo single homozygous littermates

skeleton

abnormal skeleton morphology ( J:149312 )

• skeleton phenotype is not significantly different from that of Lfng^tm1Rjo single homozygous mice

decreased caudal vertebrae number ( J:149312 )

abnormal rib morphology ( J:149312 )

limbs/digits/tail

decreased caudal vertebrae number ( J:149312 )

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco Rfng^tm1Tfv/Rfng^tm1Tfv
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:149312 )

• fewer than expected are found at weaning however survivors are viable and fertile

postnatal lethality, incomplete penetrance ( J:149312 )

• fewer than expected are found at weaning

• reduction in numbers found at weaning is not greater than that of Lfng^tm1Rjo single homozygous littermates

skeleton

abnormal skeleton morphology ( J:149312 )

• skeleton phenotype is not significantly different from that of Lfng^tm1Rjo single homozygous mice

decreased caudal vertebrae number ( J:149312 )

abnormal rib morphology ( J:149312 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:149312 )

N	• unlike in chick embryo experiments, no limb abnormalities are seen

decreased caudal vertebrae number ( J:149312 )

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