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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-RAB9A)500Repa
transgene insertion 500, Richard E Pagano
MGI:3849445
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Npc1m1N/Npc1m1N
Tg(CAG-RAB9A)500Repa/0
involves: BALB/c * C57BL/6 * CBA MGI:3849460


Genotype
MGI:3849460
cx1
Allelic
Composition
Npc1m1N/Npc1m1N
Tg(CAG-RAB9A)500Repa/0
Genetic
Background
involves: BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1m1N mutation (3 available); any Npc1 mutation (74 available)
Tg(CAG-RAB9A)500Repa mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• male mice have a 22% increase in lifespan compared to transgene-negative Npc1 homozygotes which die around 95 days of age

growth/size/body
• animals lose weight more slowly than transgene positive Npc1 homozygotes; at all time points after the 4 weeks, weight differences are significantly different
• transgene-positive animals show a trend to increased weight retention; retardation in weight loss is more pronounced for males relative to females

homeostasis/metabolism
• 80-day-old mice have reduced levels of GM2 and GM3 gangliosides (by 45 and 32%) in the cerebral cortex compared to transgene-negative Npc1 homozygotes





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory