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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mterf2Gt(OST453159)Lex
gene trap OST453159, Lexicon Genetics
MGI:3849455
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mterf2Gt(OST453159)Lex/Mterf2Gt(OST453159)Lex B6.129S5-Mterf2Gt(OST453159)Lex MGI:3849458


Genotype
MGI:3849458
hm1
Allelic
Composition
Mterf2Gt(OST453159)Lex/Mterf2Gt(OST453159)Lex
Genetic
Background
B6.129S5-Mterf2Gt(OST453159)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mterf2Gt(OST453159)Lex mutation (0 available); any Mterf2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• there is a trend of decreased body weight as mice age
• decreased bodyweight is more evident in female than male mice

behavior/neurological
• mice fed a ketogenic diet make more mistakes and take longer to find a hidden platform in a water maze after training
• mice run only 75% the distance as controls in an endurance tests
• ketogenic (high-fat, low-carb) diet fed mice only run half the distance as wild-type controls fed the same diet

cellular
• ketogenic diet increases mtDNA 1.5-fold in the brain and 3-fold in the liver
• 3-fold increase of mtDNA in skeletal muscle
• mtDNA increases to 4.5 fold over controls in skeletal muscle when mice are fed a ketogenic diet
• numbers and size of mitochondria are vastly increased in skeletal muscle
• numbers and size of mitochondria are vastly increased in skeletal muscle
• lung fibroblasts isolated from mice take significantly longer to grow on a galactose but not glucose media
• increases in citrate synthase activity
• despite increased mitochondrial mass, ATP levels in skeletal muscle are 60% of controls on a standard diet and just 30% of controls on a ketogenic diet
• mitochondria in skeletal muscles have 30-40% reduced COX activity
• when fed a ketogenic diet, mitochondria from numerous tissues have reduced COX activity

homeostasis/metabolism
• mice run only 75% the distance as controls in an endurance tests
• ketogenic (high-fat, low-carb) diet fed mice only run half the distance as wild-type controls fed the same diet

muscle
• 3-fold increase of mtDNA in skeletal muscle
• mtDNA increases to 4.5 fold over controls in skeletal muscle when mice are fed a ketogenic diet
• mice have about double the number of falls on a treadmill as do controls
• falls occur about 6-fold more than controls when mice are fed a ketogenic diet
• grip tests confirm the muscle weakness in these mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory