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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Angptl3tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:3849576
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Angptl3tm1Lex/Angptl3tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3849581
cx2
 		Angptl3tm1Lex/Angptl3tm1Lex
Apoetm1Unc/Apoetm1Unc 		involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6 MGI:3849583
cx3
 		Angptl3tm1Lex/Angptl3tm1Lex
Ldlrtm1Her/Ldlrtm1Her 		involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:3849585


Genotype
MGI:3849581
hm1
Allelic
Composition		 Angptl3tm1Lex/Angptl3tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3tm1Lex mutation (2 available); any Angptl3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating triglyceride level ( J:149912 )
• serum triglyceride levels are 60% lower than in controls




Genotype
MGI:3849583
cx2
Allelic
Composition		 Angptl3tm1Lex/Angptl3tm1Lex
Apoetm1Unc/Apoetm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3tm1Lex mutation (2 available); any Angptl3 mutation (36 available)
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:149912 )
• serum cholesterol levels are 49% lower than in Apoe null homozygote controls
decreased circulating triglyceride level ( J:149912 )
• serum triglyceride levels are 86% lower than in Apoe null homozygote controls




Genotype
MGI:3849585
cx3
Allelic
Composition		 Angptl3tm1Lex/Angptl3tm1Lex
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl3tm1Lex mutation (2 available); any Angptl3 mutation (36 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:149912 )
• serum cholesterol levels are 60% lower than in Ldlr null homozygote controls
decreased circulating triglyceride level ( J:149912 )
• serum triglyceride levels are 86% lower than in Ldlr null homozygote controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory