Phenotypes associated with this allele

• Allele Symbol: Tg(Rr141-cre)1Ksec
• Allele Name: transgene insertion 1, Katheryn S E Cheah
• Allele ID: MGI:3849597
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox9^tm2Crm/Sox9^+ Tg(Rr141-cre)1Ksec/0	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:7451331
cn2	Sox10^tm1Ngan/Sox10^+ Sox9^tm2Crm/Sox9^+ Tg(Rr141-cre)1Ksec/0	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:7451336
cn3	Sox9^tm1.1Ksec/Sox9^+ Tg(Rr141-cre)1Ksec/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:7451326
cn4	Sox10^tm1Ngan/Sox10^+ Sox9^tm1.1Ksec/Sox9^+ Tg(Rr141-cre)1Ksec/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:7451340

Genotype
MGI:7451331

cn1

• Allelic Composition: Sox9^tm2Crm/Sox9⁺; Tg(Rr141-cre)1Ksec/0
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:332093 )

N • normal cross-section of basal cochlear lumen in E15.5 embryos

Genotype
MGI:7451336

cn2

• Allelic Composition: Sox10^tm1Ngan/Sox10⁺; Sox9^tm2Crm/Sox9⁺; Tg(Rr141-cre)1Ksec/0
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

hearing/vestibular/ear

dilated cochlea ( J:332093 )

• larger cross-section of basal cochlear lumen in E15.5 embryos

Genotype
MGI:7451326

cn3

• Allelic Composition: Sox9^tm1.1Ksec/Sox9⁺; Tg(Rr141-cre)1Ksec/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

behavior/neurological

impaired righting response ( J:332093 )

• impaired contact righting starting before weaning

abnormal placing response ( J:332093 )

• onset before weaning

head tilt ( J:332093 )

• onset before weaning

head tossing ( J:332093 )

• onset before weaning

positive geotaxis ( J:332093 )

hyperactivity ( J:332093 )

• onset before weaning

circling ( J:332093 )

• onset before weaning

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:332093 )

N • normal otic vesicles in E9.5embryos

N • normal scala vestibuli morphology in adult mice

N • normal hair cell and stereocilia arrangement in organ of Corti at age P4

N • normal apoptosis rates of cochlea epithelial cells in E14.5 e

dilated cochlea ( J:332093 )

• ~3.2x larger cross-section of basal cochlear lumen in E15.5 embryos

dilated scala media ( J:332093 )

• doubled in size in adult mice

• dilation of cochlear duct starting in E15 em

small scala tympani ( J:332093 )

• ~30% smaller in adult mice

dilated endolymphatic duct ( J:332093 )

• in adult mice and E16.5 embryos

abnormal otolith morphology ( J:332093 )

• at age P9

decreased endocochlear potential ( J:332093 )

• in mature mice

nonsyndromic hearing impairment ( J:332093 )

• hearing deficit from 40 to 80 dB starting before weaning

Genotype
MGI:7451340

cn4

• Allelic Composition: Sox10^tm1Ngan/Sox10⁺; Sox9^tm1.1Ksec/Sox9⁺; Tg(Rr141-cre)1Ksec/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

hearing/vestibular/ear

dilated cochlea ( J:332093 )

• ~2.7x larger cross-section of basal cochlear lumen in E15.5 embryos