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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gcnt3tm1.1Jxm
targeted mutation 1.1, Jamey Marth
MGI:3849681
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3849708
cx2
 		Gcnt1tm1Jxm/Gcnt1tm1Jxm
Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm
Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3849710


Genotype
MGI:3849708
hm1
Allelic
Composition		 Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcnt3tm1.1Jxm mutation (0 available); any Gcnt3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal mucosa morphology ( J:149909 )
• decreases in core 2 O-glycan structures, along with increases in various core 1 O-glycan structures, are found in stomach, colon, and small intestine
abnormal intestinal absorption ( J:149909 )
• mice have more than double the amount of dextran-FITC in the sera 4 hours after gavage indicating altered barrier function
increased susceptibility to induced colitis ( J:149909 )
• mice have increased weight loss, crypt damage, area of ulcer and higher disease activity scores compared to controls after being administered 5% DSS in their drinking water

immune system
increased susceptibility to induced colitis ( J:149909 )
• mice have increased weight loss, crypt damage, area of ulcer and higher disease activity scores compared to controls after being administered 5% DSS in their drinking water
decreased IgA level ( J:149909 )
• IgA levels are significantly reduced in fecal protein with a non-significant trend to reduction also occuring in the sera
decreased IgG1 level ( J:149909 )
• IgG1 sera levels are reduced by more than half compared to controls
decreased IgG2a level ( J:149909 )
• IgG2a sera levels are reduced by about half compared to controls
decreased IgG2b level ( J:149909 )
• IgG2b sera levels are reduced compared to controls

hematopoietic system
decreased IgA level ( J:149909 )
• IgA levels are significantly reduced in fecal protein with a non-significant trend to reduction also occuring in the sera
decreased IgG1 level ( J:149909 )
• IgG1 sera levels are reduced by more than half compared to controls
decreased IgG2a level ( J:149909 )
• IgG2a sera levels are reduced by about half compared to controls
decreased IgG2b level ( J:149909 )
• IgG2b sera levels are reduced compared to controls




Genotype
MGI:3849710
cx2
Allelic
Composition		 Gcnt1tm1Jxm/Gcnt1tm1Jxm
Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm
Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcnt1tm1Jxm mutation (1 available); any Gcnt1 mutation (30 available)
Gcnt3tm1.1Jxm mutation (0 available); any Gcnt3 mutation (25 available)
Gcnt4tm1.1Jxm mutation (0 available); any Gcnt4 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal mucosa morphology ( J:149909 )
• gastric/intestinal tissues lack all core 2 O-glycan structures with a corresponding increase in various core 1 O-glycan structures

renal/urinary system
abnormal kidney morphology ( J:149909 )
• kidney tissues lack all core 2 O-glycan structures with a corresponding increase in various core 1 O-glycan structures




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory