All Phenotypes m128-7Tpo MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

m128-7Tpo
mutation 128-7, Timothy P O'Brien
MGI:3849693

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	m128-7Tpo/m128-7Tpo	involves: C57BL/6J * SSL/LeJ	MGI:3849719
cx2	Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849718

Allelic Composition	m128-7Tpo/m128-7Tpo
Genetic Background	involves: C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:149893 )

• mice exhibit the same lethality as observed in m128-7Tpo Ednrb^s-24Pub heterozygotes

Allelic Composition	Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-24Pub mutation (0 available); any Ednrb mutation (103 available)
m128-7Tpo mutation (0 available); any m128-7Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Developmental defects of Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺ embryos

mortality/aging

embryonic lethality, complete penetrance ( J:149893 )

• mice die mid-gestation

embryo

abnormal vitelline vasculature morphology ( J:149893 )

• at E10.5, yolk sacs lack mature blood vessels unlike in wild-type mice

abnormal pharyngeal arch morphology ( J:149893 )

• at E10.5

incomplete embryo turning ( J:149893 )

• at E10.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:149893 )

• at E10.5, yolk sacs lack mature blood vessels unlike in wild-type mice

abnormal direction of heart looping ( J:149893 )

• randomized

hemopericardium ( J:149893 )

• at E10.5

enlarged pericardium ( J:149893 )

• at E10.5

craniofacial

abnormal pharyngeal arch morphology ( J:149893 )

• at E10.5

homeostasis/metabolism

hemopericardium ( J:149893 )

• at E10.5

growth/size/body

abnormal head morphology ( J:149893 )

• at E10.5

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