All Phenotypes Actg1<tm1.1Erv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actg1^tm1.1Erv/Actg1^tm1.1Erv	B6.129-Actg1^tm1.1Erv	MGI:3849837
ht2	Actg1^tm1Erv/Actg1^tm1.1Erv	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4882053

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:150067 )

• some mice die prematurely

perinatal lethality, incomplete penetrance ( J:150067 )

• only one third of expected mice are born

hearing/vestibular/ear

decreased outer hair cell stereocilia number ( J:150067 )

• at 16 weeks, outer hair stereocilia are 50% degenerated or absent unlike in wild-type mice

• within the hair bundle, stereocilia are missing or shortened unlike in wild-type mice

• however, remaining stereocilia are normal

increased or absent threshold for auditory brainstem response ( J:150067 )

• progressive, beginning at 16 weeks of age

impaired hearing ( J:150067 )

• beginning at 16 weeks of age

deafness ( J:150067 )

• at 24 weeks

growth/size/body

decreased body weight ( J:150067 )

• 20% lower than wild-type mice

nervous system

decreased outer hair cell stereocilia number ( J:150067 )

• at 16 weeks, outer hair stereocilia are 50% degenerated or absent unlike in wild-type mice

• within the hair bundle, stereocilia are missing or shortened unlike in wild-type mice

• however, remaining stereocilia are normal

digestive/alimentary system

digestive/alimentary phenotype ( J:150067 )

N	• intestinal microvilli are normal

Allelic Composition	Actg1^tm1Erv/Actg1^tm1.1Erv
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actg1^tm1.1Erv mutation (0 available); any Actg1 mutation (23 available)
Actg1^tm1Erv mutation (0 available); any Actg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:167543 )

• reduction in stereocilia numbers is similar to Actg1^tm1.1Erv homozygotes

increased susceptibility to age-related hearing loss ( J:167543 )

• marked hearing loss by 28 weeks of age

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:167543 )

• reduction in stereocilia numbers is similar to Actg1^tm1.1Erv homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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