Phenotypes associated with this allele

• Allele Symbol: Tph2^tm1Bdr
• Allele Name: targeted mutation 1, Michael Bader
• Allele ID: MGI:3849838
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph2^tm1Bdr/Tph2^tm1Bdr	B6.129P2-Tph2^tm1Bdr	MGI:3849844
hm2	Tph2^tm1Bdr/Tph2^tm1Bdr	FVB.129P2-Tph2^tm1Bdr	MGI:3849845
hm3	Tph2^tm1Bdr/Tph2^tm1Bdr	involves: 129P2/OlaHsd * FVB/N	MGI:3849846

Genotype
MGI:3849844

hm1

• Allelic Composition: Tph2^tm1Bdr/Tph2^tm1Bdr
• Genetic Background: B6.129P2-Tph2^tm1Bdr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:150042 )

• Background Sensitivity: mice exhibit 53% survival compared to 89% on a congenic FVB background or 73% on a mixed 129P2/OlaHsd and C57BL/6 background

growth/size/body

decreased body size ( J:150042 )

• mice exhibit reduced body size at P3 compared to in wild-type

• handling, including food quantification and force feeding, worsens the phenotype

• however, mice reach normal size by 4 months

postnatal growth retardation ( J:150042 )

• weaning is delayed by 2 weeks

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:150042 )

• until 2 months of age

behavior/neurological

weakness ( J:150042 )

integument

abnormal skin condition ( J:150042 )

• mice exhibit softer skin than wild-type mice

Genotype
MGI:3849845

hm2

• Allelic Composition: Tph2^tm1Bdr/Tph2^tm1Bdr
• Genetic Background: FVB.129P2-Tph2^tm1Bdr

mortality/aging

premature death ( J:150042 )

• Background Sensitivity: mice exhibit 89% survival compared to 53% on a congenic C57BL/6 background or 73% on a mixed 129P2/OlaHsd and C57BL/6 background

behavior/neurological

weakness ( J:150042 )

abnormal sleep pattern ( J:150042 )

• percent of time spent asleep between 12 a.m. and 6 p.m. is increased compared to in wild-type mice

growth/size/body

decreased body size ( J:150042 )

• mice exhibit reduced body size at P3 compared to in wild-type

• handling, including food quantification and force feeding, worsens the phenotype

• however, mice reach normal size by 4 months

postnatal growth retardation ( J:150042 )

• weaning is delayed by 2 weeks

cardiovascular system

abnormal circadian regulation of systemic arterial blood pressure ( J:150042 )

• decreased between 12 a.m. and 6 p.m

abnormal circadian regulation of heart rate ( J:150042 )

• decreased between 12 a.m. and 6 p.m

respiratory system

decreased pulmonary respiratory rate ( J:150042 )

• between 12 a.m. and 6 p.m

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:150042 )

• until 2 months of age

integument

abnormal skin condition ( J:150042 )

• mice exhibit softer skin than wild-type mice

Genotype
MGI:3849846

hm3

• Allelic Composition: Tph2^tm1Bdr/Tph2^tm1Bdr
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

premature death ( J:150042 )

• Background Sensitivity: mice exhibit 27% lethality within the first 4 weeks of life compared to 11% on a congenic FVB background and 47% on a congenic C57BL/6 background

behavior/neurological

increased aggression ( J:150042 )

• male and female mice exhibit increased aggression compared with wild-type mice

increased aggression towards female mice ( J:150042 )

• female mice exhibit aggression towards other females unlike wild-type mice

induced hyperactivity ( J:150042 )

• during the first hour of exposure to cold conditions

abnormal sleep pattern ( J:150042 )

• during the daytime, mice sleep more frequently and for longer periods compared with wild-type mice

abnormal maternal nurturing ( J:150042 )

♀ • within days of birth of giving birth, mothers begin to exhibit neglect of their young and often cannibalize them

♀ • however, at birth mothers nurse pups and organize and keep a nest

♀ • most pups of homozygous mothers are dead within 2 to 3 days after birth

abnormal pup retrieval ( J:150042 )

♀ • at P1, 8 of 9 mothers fail to retrieve scattered young within 30 minutes unlike wild-type mothers

pup cannibalization ( J:150042 )

♀ • in cross-fostering experiments, mothers cannibalize 30% of whole litters born by wild-type mothers unlike wild-type mothers fostering pups born from homozygous mothers

homeostasis/metabolism

impaired adaptive thermogenesis ( J:150042 )

• following exposure to cold, mice exhibit a more pronounced drop in body temperature than similarly treated wild-type mice

decreased circulating insulin-like growth factor I level ( J:150042 )

• until 2 months of age

decreased serotonin level ( J:150042 )

• 5-HT levels in the striatum, frontal cortex, hippocampus, and hypothalamus are lower than in wild-type mice

• however, 5-HT levels in the duodenum, liver, blood, and spleen are normal

growth/size/body

decreased body size ( J:150042 )

• mice exhibit reduced body size at P3 compared to in wild-type

• handling, including food quantification and force feeding, worsens the phenotype

• however, mice reach normal size by 4 months

decreased body weight ( J:150042 )

postnatal growth retardation ( J:150042 )

• weaning is delayed by 2 weeks

cardiovascular system

abnormal circadian regulation of systemic arterial blood pressure ( J:150042 )

• during the nighttime

abnormal circadian regulation of heart rate ( J:150042 )

• during the nighttime

respiratory system

decreased pulmonary respiratory rate ( J:150042 )

• respiration rate (breaths per minute) is decreased compared to in wild-type mice

• however, the circadian rhythm of respiration rates is normal

nervous system

abnormal autonomic nervous system physiology ( J:150042 )

• autonomic control of sleep, breathing, thermoregulation, heart rate, and blood pressure is impaired

taste/olfaction

taste/olfaction phenotype ( J:150042 )

N • female mice exhibit normal olfaction in a hidden cookie challenge

integument

abnormal skin condition ( J:150042 )

• mice exhibit softer skin than wild-type mice