Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm1.1Oyam
• Allele Name: targeted mutation 1.1, Yoko Yamagata
• Allele ID: MGI:3849851
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^tm1.1Oyam/Camk2a^tm1.1Oyam	either: B6.Cg-Camk2a^tm1.1Oyam or (involves: C57BL/6 * CBA * ICR)	MGI:3849859
ht2	Camk2a^tm1.1Oyam/Camk2a^+	either: B6.Cg-Camk2a^tm1.1Oyam or (involves: C57BL/6 * CBA * ICR)	MGI:3849860

Genotype
MGI:3849859

hm1

• Allelic Composition: Camk2a^tm1.1Oyam/Camk2a^tm1.1Oyam
• Genetic Background: either: B6.Cg-Camk2a^tm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:150046 )

• survival rate in 6 months is 79% compared to 99% for wild-type mice

premature death ( J:150046 )

behavior/neurological

abnormal avoidance learning behavior ( J:150046 )

• mice exhibit impaired avoidance learning by entering the dark (shock) compartment without hesitation 24 hours after training unlike wild-type mice

• after multitrial training, mice exhibit reduced avoidance behavior compared with wild-type mice

abnormal spatial learning ( J:150046 )

• mice fail to exhibit increased latencies between the first and second trials during avoidance training with a dark (shock) compartment

• however, mice eventually learn to refrain from entering the dark (shock) compartment

abnormal short-term spatial reference memory ( J:150046 )

• mice enter the dark (shock) compartment 40 minutes after training unlike wild-type mice

hyperactivity ( J:150046 )

sporadic seizures ( J:150046 )

• after 10 weeks, mice exhibit mild sporadic limbic seizures unlike wild-type mice

nervous system

sporadic seizures ( J:150046 )

• after 10 weeks, mice exhibit mild sporadic limbic seizures unlike wild-type mice

abnormal neuron morphology ( J:150046 )

• tetanus-induced spine remodeling is severely impaired compared to in wild-type mice

reduced long-term potentiation ( J:150046 )

• titanic stimulation fails to induce long term potentiation and repeated tetanus only produces slight potentiation unlike in wild-type mice

Genotype
MGI:3849860

ht2

• Allelic Composition: Camk2a^tm1.1Oyam/Camk2a⁺
• Genetic Background: either: B6.Cg-Camk2a^tm1.1Oyam or (involves: C57BL/6 * CBA * ICR)

mortality/aging

decreased survivor rate ( J:150046 )

• survival rate in 6 months is 95% compared to 99% for wild-type mice

premature death ( J:150046 )

behavior/neurological

hyperactivity ( J:150046 )

sporadic seizures ( J:150046 )

• after 10 weeks, mice exhibit mild sporadic limbic seizures unlike wild-type mice

nervous system

sporadic seizures ( J:150046 )

• after 10 weeks, mice exhibit mild sporadic limbic seizures unlike wild-type mice