Phenotypes associated with this allele

• Allele Symbol: Cebpb^tm1.1Acle
• Allele Name: targeted mutation 1.1, Achim Leutz
• Allele ID: MGI:3849861
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cebpb^tm1.1Acle/Cebpb^tm1.1Acle	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3849865
ht2	Cebpb^tm1.1Acle/Cebpb^+	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3849866

Genotype
MGI:3849865

hm1

• Allelic Composition: Cebpb^tm1.1Acle/Cebpb^tm1.1Acle
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:150006 )

• slightly fewer than expected mice are born (18% compared to the expected 25%)

skeleton

enhanced osteoblast differentiation ( J:150006 )

• enhanced

abnormal osteoblast physiology ( J:150006 )

• the osteoblast surface to bone surface is increased compared to in wild-type mice

abnormal osteoclast morphology ( J:150006 )

• mice exhibit enlarged osteoclasts and an increase in the number of multinucleated osteoclasts compared to in wild-type mice

abnormal osteoclast differentiation ( J:150006 )

• bone marrow cells exhibit enhanced osteoclast differentiation with increased number of mononuclear and multinucleated osteoclasts compared to in wild-type mice

abnormal osteoclast physiology ( J:150006 )

• enhanced osteoclast formation is accompanied by enhanced osteoclast activity

• autocrine stimulation by TNFalpha enhances osteoclastogenesis compared to in wild-type mice

• the number of osteoclasts to bone perimeter is decreased compared to in wild-type mice

increased bone volume ( J:150006 )

• bone volume is increased 1.7-fold compared to in wild-type mice

abnormal bone trabecula morphology ( J:150006 )

• the thickness of bone trabeculae is increased compared to in wild-type mice

increased bone trabecula number ( J:150006 )

• the number of bone trabeculae is increased compared to in wild-type mice

increased bone mineralization ( J:150006 )

• mineral apposition is increased compared to in wild-type mice

increased bone ossification ( J:150006 )

• bone formation is increased compared to in wild-type mice

increased bone resorption ( J:150006 )

immune system

abnormal osteoclast morphology ( J:150006 )

• mice exhibit enlarged osteoclasts and an increase in the number of multinucleated osteoclasts compared to in wild-type mice

abnormal osteoclast differentiation ( J:150006 )

• bone marrow cells exhibit enhanced osteoclast differentiation with increased number of mononuclear and multinucleated osteoclasts compared to in wild-type mice

abnormal osteoclast physiology ( J:150006 )

• enhanced osteoclast formation is accompanied by enhanced osteoclast activity

• autocrine stimulation by TNFalpha enhances osteoclastogenesis compared to in wild-type mice

• the number of osteoclasts to bone perimeter is decreased compared to in wild-type mice

hematopoietic system

abnormal osteoclast morphology ( J:150006 )

• mice exhibit enlarged osteoclasts and an increase in the number of multinucleated osteoclasts compared to in wild-type mice

abnormal osteoclast differentiation ( J:150006 )

• bone marrow cells exhibit enhanced osteoclast differentiation with increased number of mononuclear and multinucleated osteoclasts compared to in wild-type mice

abnormal osteoclast physiology ( J:150006 )

• enhanced osteoclast formation is accompanied by enhanced osteoclast activity

• autocrine stimulation by TNFalpha enhances osteoclastogenesis compared to in wild-type mice

• the number of osteoclasts to bone perimeter is decreased compared to in wild-type mice

cellular

enhanced osteoblast differentiation ( J:150006 )

• enhanced

abnormal osteoclast differentiation ( J:150006 )

• bone marrow cells exhibit enhanced osteoclast differentiation with increased number of mononuclear and multinucleated osteoclasts compared to in wild-type mice

abnormal osteoblast physiology ( J:150006 )

• the osteoblast surface to bone surface is increased compared to in wild-type mice

Genotype
MGI:3849866

ht2

• Allelic Composition: Cebpb^tm1.1Acle/Cebpb⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

skeleton

abnormal skeleton morphology ( J:150006 )

• mice exhibit an intermediate phenotype between homozygotes and wild-type mice