Phenotypes associated with this allele

• Allele Symbol: Mrgprd^{tm2.1(Hbegf)Mjz}
• Allele Name: targeted mutation 2.1, Mark J Zylka
• Allele ID: MGI:3849868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mrgprd^tm1Mjz/Mrgprd^tm2.1(Hbegf)Mjz	involves: 129S1/Sv	MGI:3849872

Genotype
MGI:3849872

ht1

• Allelic Composition: Mrgprd^tm1Mjz/Mrgprd^{tm2.1(Hbegf)Mjz}
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:149999 )

N • behavioral responses to noxious heat and cold stimuli are normal

hyporesponsive to tactile stimuli ( J:149999 )

• diphtheria-treated mice exhibit double the threshold to paw withdrawal in response to calibrated von Frey filaments unlike similarly treated wild-type mice

• elevated response threshold following diphtheria treatment persists for at least 31 days

• diphtheria-treated mice exposed to capsaicin do not exhibit any further decrease in mechanosensitivity

abnormal nociception after inflammation ( J:149999 )

• diphtheria-treated mice exposed to complete Freund's adjuvant exhibit higher mechanical nociception threshold compared to in similarly treated wild-type mice

nervous system

abnormal neuron morphology ( J:149999 )

• treatment with diphtheria toxin results in a greater than 98% ablation of Mrgprd+ cell bodies in the dorsal root ganglion and in central and peripheral fibers