Phenotypes associated with this allele

• Allele Symbol: Thrb^tm6.1Few
• Allele Name: targeted mutation 6.1, Fredric E Wondisford
• Allele ID: MGI:3849878
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm6.1Few/Thrb^tm6.1Few	involves: 129 * C57BL/6	MGI:3849881
ht2	Thrb^tm6.1Few/Thrb^+	involves: 129 * C57BL/6	MGI:3849882

Genotype
MGI:3849881

hm1

• Allelic Composition: Thrb^tm6.1Few/Thrb^tm6.1Few
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150008 )

N • thyroid-stimulating hormone serum levels are normal

increased circulating thyroxine level ( J:150008 )

• 3 to 4 times higher than in wild-type mice

increased circulating triiodothyronine level ( J:150008 )

• 3 to 4 times higher than in wild-type mice

growth/size/body

decreased body weight ( J:150008 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:150008

Genotype
MGI:3849882

ht2

• Allelic Composition: Thrb^tm6.1Few/Thrb⁺
• Genetic Background: involves: 129 * C57BL/6

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150008 )

N • thyroid-stimulating hormone serum levels are normal

increased circulating thyroxine level ( J:150008 )

• 2-fold higher than in wild-type mice

increased circulating triiodothyronine level ( J:150008 )

• 2-fold higher than in wild-type mice

growth/size/body

decreased body weight ( J:150008 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:150008