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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfb1tm2.1Doe
targeted mutation 2.1, Thomas Doetschman
MGI:3849964
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tgfb1tm1Doe/Tgfb1tm2.1Doe
Tg(Lck-cre)548Jxm/? 		involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA MGI:3849995
cn2
 		Tg(Lck-cre)548Jxm/?
Tgfb1tm2.1Doe/Tgfb1tm2.1Doe 		involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA MGI:3849994


Genotype
MGI:3849995
cn1
Allelic
Composition		 Tgfb1tm1Doe/Tgfb1tm2.1Doe
Tg(Lck-cre)548Jxm/?
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (35 available)
Tgfb1tm2.1Doe mutation (0 available); any Tgfb1 mutation (35 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

immune system
salivary gland inflammation ( J:150024 )
• salivary gland inflammation is observed in mice at 5 months of age
lung inflammation ( J:150024 )
• inflammation is observed in the lungs at 5 months of age

respiratory system
lung inflammation ( J:150024 )
• inflammation is observed in the lungs at 5 months of age

digestive/alimentary system
salivary gland inflammation ( J:150024 )
• salivary gland inflammation is observed in mice at 5 months of age

endocrine/exocrine glands
salivary gland inflammation ( J:150024 )
• salivary gland inflammation is observed in mice at 5 months of age




Genotype
MGI:3849994
cn2
Allelic
Composition		 Tg(Lck-cre)548Jxm/?
Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb1tm2.1Doe mutation (0 available); any Tgfb1 mutation (35 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

growth/size/body
weight loss ( J:150024 )
• there is more than a 10% reduction in mean weight of mice compared to controls at 5 months of age

digestive/alimentary system
salivary gland inflammation ( J:150024 )
• modest salivary gland inflammation is observed in mice at 5 months of age

immune system
abnormal T cell subpopulation ratio ( J:150024 )
• there are slightly more CD8+ T cells than CD4+ T cells among splenocytes
abnormal T cell activation ( J:150024 )
• there is a higher percentage of T cells expressing activation markers
decreased thymus weight ( J:150024 )
• thymus weight at 5 months of age is reduced by more than a third
thymus hypoplasia ( J:150024 )
• thymus cellularity is reduced by more than two-thirds at 1 month of age
decreased spleen weight ( J:150024 )
• spleen weight is reduced by about a third at 2 months of age
spleen hypoplasia ( J:150024 )
• spleen cellularity is about half that of controls at 5 months of age
increased interferon-gamma secretion ( J:150024 )
• interferon-gamma secretion is enhanced in mutant T cells when activated with various stimuli
increased interleukin-2 secretion ( J:150024 )
• interleukin-2 secretion is enhanced in mutant T cells when activated with various stimuli
salivary gland inflammation ( J:150024 )
• modest salivary gland inflammation is observed in mice at 5 months of age
lung inflammation ( J:150024 )
• modest inflammation is observed in the lungs at 5 months of age

respiratory system
lung inflammation ( J:150024 )
• modest inflammation is observed in the lungs at 5 months of age

endocrine/exocrine glands
salivary gland inflammation ( J:150024 )
• modest salivary gland inflammation is observed in mice at 5 months of age
decreased thymus weight ( J:150024 )
• thymus weight at 5 months of age is reduced by more than a third
thymus hypoplasia ( J:150024 )
• thymus cellularity is reduced by more than two-thirds at 1 month of age

hematopoietic system
decreased thymus weight ( J:150024 )
• thymus weight at 5 months of age is reduced by more than a third
thymus hypoplasia ( J:150024 )
• thymus cellularity is reduced by more than two-thirds at 1 month of age
abnormal T cell subpopulation ratio ( J:150024 )
• there are slightly more CD8+ T cells than CD4+ T cells among splenocytes
decreased spleen weight ( J:150024 )
• spleen weight is reduced by about a third at 2 months of age
spleen hypoplasia ( J:150024 )
• spleen cellularity is about half that of controls at 5 months of age
abnormal T cell activation ( J:150024 )
• there is a higher percentage of T cells expressing activation markers




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory