Phenotypes associated with this allele

• Allele Symbol: Erbin^tm1Line
• Allele Name: targeted mutation 1, Lin Mei
• Allele ID: MGI:3849990
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbin^tm1Line/Erbin^tm1Line	involves: 129P2/OlaHsd * C57BL/6	MGI:3849998

Genotype
MGI:3849998

hm1

• Allelic Composition: Erbin^tm1Line/Erbin^tm1Line
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hypomyelination and abnormal axonal segregation in Remak bundles of Erbin^tm1Line/Erbin^tm1Line sciatic nerves

nervous system

abnormal axon morphology ( J:149996 )

• the average size of unmyelinated axons in the sciatic nerve is smaller than in wild-type mice

abnormal myelin sheath morphology ( J:149996 )

• myelin of axons ranging in size is thinner than in wild-type mice

abnormal myelination ( J:149996 )

• mice exhibit impaired myelination

• the number of unmyelinated axons in the Remak bundles in sciatic nerves is increased compared to in wild-type mice

• the percentage of pockets containing more axons is increased in the sciatic nerve compared to in wild-type mice

• however, mice exhibit normal radical sorting, myelin initiation, and compaction are normal

decreased nerve conduction velocity ( J:149996 )

behavior/neurological

hyporesponsive to tactile stimuli ( J:149996 )

• the sensory threshold, smallest strength of Von Frey Hair to generate 80% hind paw response, is increased compared to in wild-type mice