Phenotypes associated with this allele

• Allele Symbol: Erbin^{Gt(BGA258)Byg}
• Allele Name: gene trap BGA258, BayGenomics
• Allele ID: MGI:3849991
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbin^Gt(BGA258)Byg/Erbin^Gt(BGA258)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3849999

Genotype
MGI:3849999

hm1

• Allelic Composition: Erbin^{Gt(BGA258)Byg}/Erbin^{Gt(BGA258)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Deficits in myelination and entheathment of axons in Erbin^{Gt(BGA258)Byg}/Erbin^{Gt(BGA258)Byg} mice

nervous system

abnormal axon morphology ( J:149996 )

• the average size of unmyelinated axons in the sciatic nerve is smaller than in wild-type mice

abnormal myelin sheath morphology ( J:149996 )

• myelinated axons exhibit thinner myelin compared to in wild-type mice without changes in ultrastructure and periodicity

abnormal myelination ( J:149996 )

• mice exhibit impaired myelination

• the number of unmyelinated axons in the Remak bundles in sciatic nerves is increased compared to in wild-type mice

• the percentage of pockets containing more axons is increased in the sciatic nerve compared to in wild-type mice

decreased nerve conduction velocity ( J:149996 )

behavior/neurological

hyporesponsive to tactile stimuli ( J:149996 )

• the sensory threshold, smallest strength of Von Frey Hair to generate 80% hind paw response, is increased compared to in wild-type mice