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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sun2tm1Mhan
targeted mutation 1, Min Han
MGI:3850087
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sun2tm1Mhan/Sun2tm1Mhan involves: 129S6/SvEvTac MGI:3850091
cx2
 		Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2+ 		involves: 129S6/SvEvTac MGI:3850093
cx3
 		Sun1tm1Mhan/Sun1+
Sun2tm1Mhan/Sun2tm1Mhan 		involves: 129S6/SvEvTac MGI:3850094
cx4
 		Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2tm1Mhan 		involves: 129S6/SvEvTac MGI:3850092


Genotype
MGI:3850091
hm1
Allelic
Composition		 Sun2tm1Mhan/Sun2tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:150047 )
• mice exhibit no obvious abnormalities in growth and development

reproductive system
reproductive system phenotype ( J:150047 )
N
• mice are fertile

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:194486 )
N
• mice exhibit normal hearing




Genotype
MGI:3850093
cx2
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle morphology ( J:150047 )
• 63% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice




Genotype
MGI:3850094
cx3
Allelic
Composition		 Sun1tm1Mhan/Sun1+
Sun2tm1Mhan/Sun2tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle morphology ( J:150047 )
• 49% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice




Genotype
MGI:3850092
cx4
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:150047 )
• mice die soon after birth
• however, neural expression of Unc84b rescues neonatal lethality

muscle
abnormal muscle morphology ( J:150047 )
• 81% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice

growth/size/body
decreased birth body size ( J:150047 )
• reduced body size at birth

homeostasis/metabolism
cyanosis ( J:150047 )
• at birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory