Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• mean heart size is greater than in wild-type females at 9 weeks of age, however smaller than in hemizygous Tg(Myh6-BRUNOL4*)10Coop females, indicating partial rescue of the cardiac phenotype
• percentage of females with cardiac hypertrophy is lower than in Tg(Myh6-BRUNOL4*)10Coop females
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mortality/aging
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• greater percentage of double mutant females survive to 9 weeks of age than single Tg(Myh6-BRUNOL4*)10Coop females, however some premature death is seen compared to wild-type females
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growth/size/body
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• mean heart size is greater than in wild-type females at 9 weeks of age, however smaller than in hemizygous Tg(Myh6-BRUNOL4*)10Coop females, indicating partial rescue of the cardiac phenotype
• percentage of females with cardiac hypertrophy is lower than in Tg(Myh6-BRUNOL4*)10Coop females
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• premature death is commonly seen in mutants, however mutants do not show overt signs of poor health prior to death
• 91% of males, but only 27% of females are still alive at 24 weeks of age
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• females do not tolerate pregnancy, with females dying during pregnancy
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cardiovascular system
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• lungs of affected 9 week old females show dilated veins with muscular hypertrophy of the wall, indicative of chronically elevated left-ventricular-end diastolic pressure
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• at 3 weeks of age, but not at 4 days of age, females exhibit cardiac fibrosis and myocyte degenerative changes indicative of myocytolysis
• at 9 weeks of age, females exhibit more extensive degenerative myocytolysis, with continuing loss of myofibers and fibrosis
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• left atrial dilation is seen at 3 and 9 weeks of age
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• pregnant females exhibit cardiac hypertrophy, with the heart weight almost 3 times that of control females
• virgin 8 week old females and 9 week old males also exhibit cardiac hypertrophy; heart size of males is not increased as much as in females
• 3 week old females exhibit mild cardiac enlargement that is primarily left side with a globular left ventricular contour
• 9 week old females show striking enlarged hearts, with expansion of the chambers but without wall thinning, indicating both cardiac hypertrophy and dilation
• fewer than 50% of males develop cardiac hypertrophy within the first 24 weeks while 85% of females develop cardiac hypertrophy by 6 weeks of age
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• at 3 weeks of age, but not at 4 days of age, females exhibit cardiac fibrosis and myocyte degenerative changes indicative of myocytolysis
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• at 9 weeks of age, females show profound cardiac dysfunction, with an increase in end diastolic and end systolic dimensions
• however, under anesthesia, females have normal heart rates with no sign of persistent arrhythmia
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• 9 week old females show striking enlarged hearts, with expansion of the chambers but without wall thinning, indicating both cardiac hypertrophy and dilation
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• peak early-filling velocity is reduced, whereas the isovolumic relaxation time and Tei index are increased
• no discernible A wave is seen on the transmitral Doppler, indicating that despite the presence of a clear electrical activation of the atria, there is no significant atrial contribution to left-ventricular filling
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• fractional shortening is severely reduced, indicating impaired contraction
• peak aortic flow velocity and mean and peak aortic accelerations are reduced, whereas the isovolumic contraction time is elevated
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homeostasis/metabolism
muscle
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• at 3 weeks of age, but not at 4 days of age, females exhibit cardiac fibrosis and myocyte degenerative changes indicative of myocytolysis
• at 9 weeks of age, females exhibit more extensive degenerative myocytolysis, with continuing loss of myofibers and fibrosis
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• 9 week old females show striking enlarged hearts, with expansion of the chambers but without wall thinning, indicating both cardiac hypertrophy and dilation
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• fractional shortening is severely reduced, indicating impaired contraction
• peak aortic flow velocity and mean and peak aortic accelerations are reduced, whereas the isovolumic contraction time is elevated
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respiratory system
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• by 9 weeks of age, lungs of affected females look gray and swollen compared to wild-type
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• lungs of affected 9 week old females show dilated veins with muscular hypertrophy of the wall, indicative of chronically elevated left-ventricular-end diastolic pressure
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• by 9 weeks of age wet lung weights are more than twice those of wild-type littermates
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growth/size/body
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• pregnant females exhibit cardiac hypertrophy, with the heart weight almost 3 times that of control females
• virgin 8 week old females and 9 week old males also exhibit cardiac hypertrophy; heart size of males is not increased as much as in females
• 3 week old females exhibit mild cardiac enlargement that is primarily left side with a globular left ventricular contour
• 9 week old females show striking enlarged hearts, with expansion of the chambers but without wall thinning, indicating both cardiac hypertrophy and dilation
• fewer than 50% of males develop cardiac hypertrophy within the first 24 weeks while 85% of females develop cardiac hypertrophy by 6 weeks of age
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• by 9 weeks of age wet lung weights are more than twice those of wild-type littermates
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