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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb1tm3.2Sor
targeted mutation 3.2, Philippe Soriano
MGI:3850116
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Efnb1tm3.2Sor/Efnb1tm3.2Sor involves: 129S4/SvJaeSor MGI:3850136
hm2
 		Efnb1tm3.2Sor/Efnb1tm3.2Sor involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:3850137
ht3
 		Efnb1tm3.2Sor/Efnb1+ involves: 129S4/SvJaeSor MGI:3850135
ht4
 		Efnb1tm3.2Sor/Efnb1+ involves: 129S4/SvJaeSor * C57BL/6 MGI:3850139
ot5
 		Efnb1tm3.2Sor/Y involves: 129S4/SvJaeSor MGI:3850134
ot6
 		Efnb1tm3.2Sor/Y involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:3850138


Genotype
MGI:3850136
hm1
Allelic
Composition		 Efnb1tm3.2Sor/Efnb1tm3.2Sor
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal corpus callosum morphology ( J:150043 )
• at E17.5, corpus callosum axons fail to cross the midline and accumulate ipsilateral bundles unlike in wild-type mice
• the corpus callosum appear defasciculated and wandering axon fibers are visible unlike in wild-type mice
absent corpus callosum ( J:150043 )
• Background Sensitivity: in 8 of 10 mice unlike mice on a mixed 129S4 and C57BL/6 background

skeleton
skeleton phenotype ( J:150043 )
N
• mice exhibit normal skeletal development




Genotype
MGI:3850137
hm2
Allelic
Composition		 Efnb1tm3.2Sor/Efnb1tm3.2Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:150043 )
N
• mice exhibit normal corpus callosum development unlike on a 129S4 background




Genotype
MGI:3850135
ht3
Allelic
Composition		 Efnb1tm3.2Sor/Efnb1+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent corpus callosum ( J:150043 )
• in 2 of 2 mice

skeleton
skeleton phenotype ( J:150043 )
N
• mice exhibit normal skeletal development




Genotype
MGI:3850139
ht4
Allelic
Composition		 Efnb1tm3.2Sor/Efnb1+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:150043 )
N
• mice exhibit normal brain morphology




Genotype
MGI:3850134
ot5
Allelic
Composition		 Efnb1tm3.2Sor/Y
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal corpus callosum morphology ( J:150043 )
• at E17.5, corpus callosum axons fail to cross the midline and accumulate ipsilateral bundles unlike in wild-type mice
• the corpus callosum appear defasciculated and wandering axon fibers are visible unlike in wild-type mice
absent corpus callosum ( J:150043 )
• Background Sensitivity: 8 of 10 mice lack a corpus callosum unlike mice with a mixed 129S4 and C57BL/6 background

skeleton




Genotype
MGI:3850138
ot6
Allelic
Composition		 Efnb1tm3.2Sor/Y
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:150043 )
N
• mice exhibit normal corpus callosum development unlike on a 129S4 background




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory