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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dicer1tm1.2Mnn
targeted mutation 1.2, Jeff Mann
MGI:3850193
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Alpltm1(cre)Nagy/Alpl+
Dicer1tm1.1Mnn/Dicer1tm1.2Mnn 		involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:3850213
cn2
 		Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Tg(Zp3-cre)93Knw/0 		involves: 129S1/SvImJ * C57BL/6J MGI:3850212


Genotype
MGI:3850213
cn1
Allelic
Composition		 Alpltm1(cre)Nagy/Alpl+
Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (352 available)
Dicer1tm1.1Mnn mutation (0 available); any Dicer1 mutation (96 available)
Dicer1tm1.2Mnn mutation (0 available); any Dicer1 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles and have scattered chromosomes unlike in wild-type oocytes
abnormal meiotic spindle morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles

cellular
abnormal oocyte morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles and have scattered chromosomes unlike in wild-type oocytes
abnormal meiotic spindle morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles




Genotype
MGI:3850212
cn2
Allelic
Composition		 Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1.1Mnn mutation (0 available); any Dicer1 mutation (96 available)
Dicer1tm1.2Mnn mutation (0 available); any Dicer1 mutation (96 available)
Tg(Zp3-cre)93Knw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:150221 )
• nearly all ovulated oocytes exhibit defects in spindle and scattered chromosomes unlike in wild-type oocytes
abnormal female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, oocytes contain abnormal chromosome arrangement and multiple spindles unlike wild-type oocytes
• wild-type germinal vesicles transplanted into oocytes exhibit abnormal meiosis
• however, transplantation of the germinal vesicle into a wild-type oocyte normalizes meiosis
abnormal spindle assembly in female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, mutant oocytes contain multiple spindles
female infertility ( J:150221 )
• despite normal numbers of oocytes, female mice are infertile

cellular
abnormal oocyte morphology ( J:150221 )
• nearly all ovulated oocytes exhibit defects in spindle and scattered chromosomes unlike in wild-type oocytes
abnormal female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, oocytes contain abnormal chromosome arrangement and multiple spindles unlike wild-type oocytes
• wild-type germinal vesicles transplanted into oocytes exhibit abnormal meiosis
• however, transplantation of the germinal vesicle into a wild-type oocyte normalizes meiosis
abnormal spindle assembly in female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, mutant oocytes contain multiple spindles




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory