About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dicer1tm1.2Mnn
targeted mutation 1.2, Jeff Mann
MGI:3850193
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Alpltm1(cre)Nagy/Alpl+
Dicer1tm1.1Mnn/Dicer1tm1.2Mnn 		involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:3850213
cn2
 		Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Tg(Zp3-cre)93Knw/0 		involves: 129S1/SvImJ * C57BL/6J MGI:3850212


Genotype
MGI:3850213
cn1
Allelic
Composition		 Alpltm1(cre)Nagy/Alpl+
Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (352 available)
Dicer1tm1.1Mnn mutation (0 available); any Dicer1 mutation (96 available)
Dicer1tm1.2Mnn mutation (0 available); any Dicer1 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles and have scattered chromosomes unlike in wild-type oocytes
abnormal meiotic spindle morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles

cellular
abnormal oocyte morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles and have scattered chromosomes unlike in wild-type oocytes
abnormal meiotic spindle morphology ( J:150221 )
• half of the ovulated oocytes exhibit defects in spindles




Genotype
MGI:3850212
cn2
Allelic
Composition		 Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1.1Mnn mutation (0 available); any Dicer1 mutation (96 available)
Dicer1tm1.2Mnn mutation (0 available); any Dicer1 mutation (96 available)
Tg(Zp3-cre)93Knw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:150221 )
• nearly all ovulated oocytes exhibit defects in spindle and scattered chromosomes unlike in wild-type oocytes
abnormal female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, oocytes contain abnormal chromosome arrangement and multiple spindles unlike wild-type oocytes
• wild-type germinal vesicles transplanted into oocytes exhibit abnormal meiosis
• however, transplantation of the germinal vesicle into a wild-type oocyte normalizes meiosis
abnormal spindle assembly in female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, mutant oocytes contain multiple spindles
female infertility ( J:150221 )
• despite normal numbers of oocytes, female mice are infertile

cellular
abnormal oocyte morphology ( J:150221 )
• nearly all ovulated oocytes exhibit defects in spindle and scattered chromosomes unlike in wild-type oocytes
abnormal female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, oocytes contain abnormal chromosome arrangement and multiple spindles unlike wild-type oocytes
• wild-type germinal vesicles transplanted into oocytes exhibit abnormal meiosis
• however, transplantation of the germinal vesicle into a wild-type oocyte normalizes meiosis
abnormal spindle assembly in female meiosis ( J:150221 )
• 8 hours post germinal vesicle break-down, mutant oocytes contain multiple spindles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory