Phenotypes associated with this allele

• Allele Symbol: Slfn2^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3850348
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slfn2^m1Btlr/Slfn2^m1Btlr	C57BL/6J-Slfn2^m1Btlr	MGI:4441072

Genotype
MGI:4441072

hm1

• Allelic Composition: Slfn2^m1Btlr/Slfn2^m1Btlr
• Genetic Background: C57BL/6J-Slfn2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158985 )

• 4 to 5 days after intravenous injection with Listeria monocytogenes, mice die unlike similarly treated wild-type mice

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:158985 )

• 6 to 8 days following inoculation with MCMV (mouse cytomegalovirus), all mice die unlike similarly treated wild-type mice

• however, transplantation of wild-type bone marrow rescues induced lethality

immune system

increased neutrophil cell number ( J:158985 )

• L. monocytogenes-infected mice exhibit increased neutrophil percent compared with similarly treated wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158985 )

• the percent of CD4+ cells in the spleen and lymph is reduced compared to in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:158985 )

• the percent of CD8+ cells in the spleen, lymph, and blood is reduced compared to in wild-type mice

• LCMV-infected mice have fewer CD8+ T cells than in similarly treated wild-type mice

• restimulation of splenocytes from LCMV-infected mice results in fewer IFN-gamma-producing CD8+ T cells compared with similarly treated wild-type mice

decreased monocyte cell number ( J:158985 )

• mice exhibit a slightly lower percent of monocytes in the blood and spleen compared with wild-type mice

• L. monocytogenes-infected mice exhibit lower monocytes in the blood and spleen compared with similarly treated wild-type mice

abnormal leukocyte physiology ( J:158985 )

• activated monocytes exhibit increased apoptosis compared with similarly treated wild-type cells

increased T cell apoptosis ( J:158985 )

• 48 hours after TCR stimulation, T cell apoptosis is higher than in similarly treated wild-type cells

• however, gamma radiation-induced apoptosis is normal and Tg(BCL2)25Wehi rescues increased apoptosis

abnormal T cell activation ( J:158985 )

• based on marker expression, T cells exhibit in a semi-activated state unlike in wild-type mice

• T cells from bone marrow transplants into Cd3e^m1Btlr mice exhibit a semi-activated state unlike similarly treated T cells derived from transplanted wild-type bone marrow

abnormal T cell proliferation ( J:158985 )

• after 24 hours, TCR stimulation produces a greater proportion of activation-competent cells compared with similarly treated cells

decreased T cell proliferation ( J:158985 )

• CD4+ T cells and CD8+ T cells fail to proliferate in response to anti-CD3 and anti-CD28 antibodies or PMA and ionomycin unlike similarly treated wild-type mice

• after 48 hours, TCR stimulation produces a fewer replicative CD8+ T cells compared with similarly treated cells

increased susceptibility to bacterial infection ( J:158985 )

• L. monocytogenes-infected mice exhibit lower monocytes in the blood and spleen compared with similarly treated wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158985 )

• 4 to 5 days after intravenous injection with Listeria monocytogenes, mice die unlike similarly treated wild-type mice

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:158985 )

• 6 to 8 days following inoculation with MCMV (mouse cytomegalovirus), all mice die unlike similarly treated wild-type mice

• however, transplantation of wild-type bone marrow rescues induced lethality

increased susceptibility to Riboviria infection ( J:158985 )

• mice exhibit impaired clearance of LCMV (lymphocytic choriomeningitis virus) compared with similarly treated wild-type mice

• LCMV-infected mice have fewer CD8+ T cells than in similarly treated wild-type mice

• restimulation of splenocytes from LCMV-infected mice results in fewer IFN-gamma-producing CD8+ T cells compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:158985 )

• monocytes treated with IFN-gamma and heat-killed L. monocytogenes fail to exhibit as great an increase in nitric oxide as in similarly treated wild-type cells

hematopoietic system

increased neutrophil cell number ( J:158985 )

• L. monocytogenes-infected mice exhibit increased neutrophil percent compared with similarly treated wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158985 )

• the percent of CD4+ cells in the spleen and lymph is reduced compared to in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:158985 )

• the percent of CD8+ cells in the spleen, lymph, and blood is reduced compared to in wild-type mice

• LCMV-infected mice have fewer CD8+ T cells than in similarly treated wild-type mice

• restimulation of splenocytes from LCMV-infected mice results in fewer IFN-gamma-producing CD8+ T cells compared with similarly treated wild-type mice

decreased monocyte cell number ( J:158985 )

• mice exhibit a slightly lower percent of monocytes in the blood and spleen compared with wild-type mice

• L. monocytogenes-infected mice exhibit lower monocytes in the blood and spleen compared with similarly treated wild-type mice

abnormal leukocyte physiology ( J:158985 )

• activated monocytes exhibit increased apoptosis compared with similarly treated wild-type cells

increased T cell apoptosis ( J:158985 )

• 48 hours after TCR stimulation, T cell apoptosis is higher than in similarly treated wild-type cells

• however, gamma radiation-induced apoptosis is normal and Tg(BCL2)25Wehi rescues increased apoptosis

abnormal T cell activation ( J:158985 )

• based on marker expression, T cells exhibit in a semi-activated state unlike in wild-type mice

• T cells from bone marrow transplants into Cd3e^m1Btlr mice exhibit a semi-activated state unlike similarly treated T cells derived from transplanted wild-type bone marrow

abnormal T cell proliferation ( J:158985 )

• after 24 hours, TCR stimulation produces a greater proportion of activation-competent cells compared with similarly treated cells

decreased T cell proliferation ( J:158985 )

• after 48 hours, TCR stimulation produces a fewer replicative CD8+ T cells compared with similarly treated cells

• CD4+ T cells and CD8+ T cells fail to proliferate in response to anti-CD3 and anti-CD28 antibodies or PMA and ionomycin unlike similarly treated wild-type mice

cellular

increased T cell apoptosis ( J:158985 )

• 48 hours after TCR stimulation, T cell apoptosis is higher than in similarly treated wild-type cells

• however, gamma radiation-induced apoptosis is normal and Tg(BCL2)25Wehi rescues increased apoptosis

abnormal T cell proliferation ( J:158985 )

• after 24 hours, TCR stimulation produces a greater proportion of activation-competent cells compared with similarly treated cells

decreased T cell proliferation ( J:158985 )

• CD4+ T cells and CD8+ T cells fail to proliferate in response to anti-CD3 and anti-CD28 antibodies or PMA and ionomycin unlike similarly treated wild-type mice

• after 48 hours, TCR stimulation produces a fewer replicative CD8+ T cells compared with similarly treated cells