Analysis Tools
mortality/aging
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• most animals become visibly ill between 7 and 13 months, and are euthanized
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immune system
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• isolated splenic B cells in week-long culture show increased survival compared to control cells
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• mice that exhibit lymphoproliferative disorders often have polyclonal B cell expansions; in some mice however, monotypic B cell expansions are observed
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• mice that exhibit lymphoproliferative disorders have polyclonal T cell expansions
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• infiltrates are observed in some cases
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• up to 3 months of age, animals exhibit mild increase in white blood cells, with no effect on lymphoid organ morphology (such as spleen weight) observed at this stage
• between 7 and 13 months, most animals appear ill and on average show a 5.5-fold increased white blood cell count (WBC)
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• most animals show splenic effacement from a diffusely infiltrative process
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• around 12 months of age, most mice become visibly ill and when necropsied, display spleen weights increased about 7.8 fold over wild-type
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• most animals show nodal effacement from a diffusely infiltrative process
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• upon necropsy, animals show variable lymphadenopathy
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hematopoietic system
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• isolated splenic B cells in week-long culture show increased survival compared to control cells
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• mice that exhibit lymphoproliferative disorders often have polyclonal B cell expansions; in some mice however, monotypic B cell expansions are observed
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• mice that exhibit lymphoproliferative disorders have polyclonal T cell expansions
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• infiltrates are observed in some cases
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• up to 3 months of age, animals exhibit mild increase in white blood cells, with no effect on lymphoid organ morphology (such as spleen weight) observed at this stage
• between 7 and 13 months, most animals appear ill and on average show a 5.5-fold increased white blood cell count (WBC)
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• most animals show splenic effacement from a diffusely infiltrative process
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• around 12 months of age, most mice become visibly ill and when necropsied, display spleen weights increased about 7.8 fold over wild-type
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neoplasm
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• different lymphoma types are observed and in almost all cases are derived from mature B cells
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skeleton
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• infiltrates are observed in some cases
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liver/biliary system
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• upon necropsy, macroscopic lesions identified as lymphocytic infiltrates are observed; periportal, perivascular and sinusoidal liver infiltrates are commonly seen
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renal/urinary system
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• upon necropsy, macroscopic lesions identified as lymphocytic infiltrates are observed
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respiratory system
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• upon necropsy, macroscopic lesions identified as lymphocytic infiltrates are observed
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digestive/alimentary system
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• upon necropsy, macroscopic lesions identified as lymphocytic infiltrates are observed
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cellular
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• isolated splenic B cells in week-long culture show increased survival compared to control cells
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• mice that exhibit lymphoproliferative disorders often have polyclonal B cell expansions; in some mice however, monotypic B cell expansions are observed
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• mice that exhibit lymphoproliferative disorders have polyclonal T cell expansions
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endocrine/exocrine glands
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• infiltrates are observed in some cases
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growth/size/body
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• around 12 months of age, most mice become visibly ill and when necropsied, display spleen weights increased about 7.8 fold over wild-type
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