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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mpz-cre)#Brn
transgene insertion, Anton Berns
MGI:3850380
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nf2tm2Gth/Nf2tm2Gth
Tg(Mpz-cre)#Brn/0
involves: 129P2/OlaHsd * FVB/N MGI:3850392
cn2
Nf2tm1Gth/Nf2tm2Gth
Tg(Mpz-cre)#Brn/0
involves: 129P2/OlaHsd * FVB/N MGI:3850403
cn3
Nf2tm2Gth/Nf2+
Tg(Mpz-cre)#Brn/0
involves: 129P2/OlaHsd * FVB/N MGI:3850405


Genotype
MGI:3850392
cn1
Allelic
Composition
Nf2tm2Gth/Nf2tm2Gth
Tg(Mpz-cre)#Brn/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)#Brn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa
• 10% of mice develop carcinoma in situ in the kidney
• 8% of mice develop osteomas and osteosarcomas
• 6% of mice develop odontomas and odontosarcomas
• 6% of mice develop odontomas and odontosarcomas
• 8% of mice develop osteomas and osteosarcomas

skeleton
• mice exhibit odontoblastic hyperplasia
• 8% of mice develop osteomas and osteosarcomas
• 8% of mice develop osteomas and osteosarcomas
• osteoblastic hyperplasia

nervous system
• 8% of mice exhibit Schwann cell hyperplasia

renal/urinary system
• 10% of mice develop carcinoma in situ in the kidney
• mice exhibit renal tubular cell hyperplasia

craniofacial
• mice exhibit odontoblastic hyperplasia

growth/size/body
• mice exhibit odontoblastic hyperplasia




Genotype
MGI:3850403
cn2
Allelic
Composition
Nf2tm1Gth/Nf2tm2Gth
Tg(Mpz-cre)#Brn/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)#Brn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit reduced viability

neoplasm
• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa
• one mouse developed a mesothelioma
• 9% of mice develop odontomas and odontosarcomas
• 9% of mice develop odontomas and odontosarcomas
• mice develop Schwann cell tumors

skeleton
• mice exhibit odontoblastic hyperplasia
• osteoblastic hyperplasia

nervous system
• mice develop Schwann cell tumors
• 59% of mice exhibit Schwann cell hyperplasia

renal/urinary system
• mice exhibit renal tubular cell hyperplasia

craniofacial
• mice exhibit odontoblastic hyperplasia

growth/size/body
• mice exhibit odontoblastic hyperplasia




Genotype
MGI:3850405
cn3
Allelic
Composition
Nf2tm2Gth/Nf2+
Tg(Mpz-cre)#Brn/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)#Brn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 6% of mice exhibit fibroadenoma in the mammary gland

neoplasm
• 6% of mice exhibit fibroadenoma in the mammary gland
• 6% of mice develop osteoma

integument
• 6% of mice exhibit fibroadenoma in the mammary gland

nervous system
N
• mice exhibit normal Schwann cell proliferation

respiratory system

craniofacial
• 6% of mice exhibit odontoblastic hyperplasia

skeleton
• 6% of mice exhibit odontoblastic hyperplasia
• 6% of mice develop osteoma

growth/size/body
• 6% of mice exhibit odontoblastic hyperplasia





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory