All Phenotypes Tg(Mpz-cre)#Brn MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Mpz-cre)#Brn
transgene insertion, Anton Berns
MGI:3850380

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nf2^tm2Gth/Nf2^tm2Gth Tg(Mpz-cre)#Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850392
cn2	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)#Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850403
cn3	Nf2^tm2Gth/Nf2⁺ Tg(Mpz-cre)#Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850405

Allelic Composition	Nf2^tm2Gth/Nf2^tm2Gth Tg(Mpz-cre)#Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)#Brn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

osseous metaplasia ( J:63264 )

• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa

increased renal carcinoma incidence ( J:63264 )

• 10% of mice develop carcinoma in situ in the kidney

increased neurofibrosarcoma incidence ( J:63264 )

increased osteosarcoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

increased odontoma incidence ( J:63264 )

• 6% of mice develop odontomas and odontosarcomas

increased odontosarcoma incidence ( J:63264 )

• 6% of mice develop odontomas and odontosarcomas

increased osteoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

skeleton

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

increased osteosarcoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

increased osteoma incidence ( J:63264 )

• 8% of mice develop osteomas and osteosarcomas

abnormal osteoblast morphology ( J:63264 )

• osteoblastic hyperplasia

nervous system

increased neurofibrosarcoma incidence ( J:63264 )

abnormal Schwann cell morphology ( J:63264 )

• 8% of mice exhibit Schwann cell hyperplasia

renal/urinary system

increased renal carcinoma incidence ( J:63264 )

• 10% of mice develop carcinoma in situ in the kidney

abnormal renal tubule morphology ( J:63264 )

• mice exhibit renal tubular cell hyperplasia

craniofacial

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

Allelic Composition	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)#Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)#Brn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

• mice exhibit reduced viability

neoplasm

osseous metaplasia ( J:63264 )

• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa

increased neurofibrosarcoma incidence ( J:63264 )

increased mesothelioma incidence ( J:63264 )

• one mouse developed a mesothelioma

increased odontoma incidence ( J:63264 )

• 9% of mice develop odontomas and odontosarcomas

increased odontosarcoma incidence ( J:63264 )

• 9% of mice develop odontomas and odontosarcomas

increased Schwannoma incidence ( J:63264 )

• mice develop Schwann cell tumors

skeleton

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

abnormal osteoblast morphology ( J:63264 )

• osteoblastic hyperplasia

nervous system

increased neurofibrosarcoma incidence ( J:63264 )

increased Schwannoma incidence ( J:63264 )

• mice develop Schwann cell tumors

abnormal Schwann cell morphology ( J:63264 )

• 59% of mice exhibit Schwann cell hyperplasia

renal/urinary system

abnormal renal tubule morphology ( J:63264 )

• mice exhibit renal tubular cell hyperplasia

craniofacial

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

Allelic Composition	Nf2^tm2Gth/Nf2⁺ Tg(Mpz-cre)#Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)#Brn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased fibroadenoma incidence ( J:63264 )

• 6% of mice exhibit fibroadenoma in the mammary gland

neoplasm

increased fibroadenoma incidence ( J:63264 )

• 6% of mice exhibit fibroadenoma in the mammary gland

increased lung adenocarcinoma incidence ( J:63264 )

• in 31% in mice

increased osteoma incidence ( J:63264 )

• 6% of mice develop osteoma

integument

increased fibroadenoma incidence ( J:63264 )

• 6% of mice exhibit fibroadenoma in the mammary gland

nervous system

nervous system phenotype ( J:63264 )

N	• mice exhibit normal Schwann cell proliferation

respiratory system

increased lung adenocarcinoma incidence ( J:63264 )

• in 31% in mice

craniofacial

abnormal tooth development ( J:63264 )

• 6% of mice exhibit odontoblastic hyperplasia

skeleton

abnormal tooth development ( J:63264 )

• 6% of mice exhibit odontoblastic hyperplasia

increased osteoma incidence ( J:63264 )

• 6% of mice develop osteoma

growth/size/body

abnormal tooth development ( J:63264 )

• 6% of mice exhibit odontoblastic hyperplasia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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