Phenotypes associated with this allele

• Allele Symbol: Tg(GFAP-CRYAB)141.6Mes
• Allele Name: transgene insertion 141.6, Albee Messing
• Allele ID: MGI:3850461
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Drd2^tm1Low/Drd2^tm1Low Tg(GFAP-CRYAB)141.6Mes/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5499901
cx2	Gfap^tm2Mes/Gfap^+ Tg(GFAP)10Mes/0 Tg(GFAP-CRYAB)141.6Mes/0	involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N	MGI:3850532
cx3	Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr Tg(GFAP)10Mes/0 Tg(GFAP-CRYAB)141.6Mes/0	involves: 129S4/SvJae * FVB/N	MGI:3850529
cx4	Gfap^tm2Mes/Gfap^+ Tg(GFAP-CRYAB)141.6Mes/0	involves: 129S7/SvEvBrd * FVB/N	MGI:3850534
cx5	Tg(GFAP)10Mes/0 Tg(GFAP-CRYAB)141.6Mes/0	involves: FVB/N	MGI:3850535

Genotype
MGI:5499901

cn1

• Allelic Composition: Drd2^tm1Low/Drd2^tm1Low; Tg(GFAP-CRYAB)141.6Mes/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:194407 )

N • astrocytes exhibit normalized RNA expression of pro-inflammatory mediators compared to in Drd2^tm1Low homozygotes

Genotype
MGI:3850532

cx2

• Allelic Composition: Gfap^tm2Mes/Gfap⁺; Tg(GFAP)10Mes/0; Tg(GFAP-CRYAB)141.6Mes/0
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N

mortality/aging

mortality/aging ( J:146191 )

N • all animals survive compared to Tg(GFAP-Cryab)141.6Mes-positive double mutants which die around 30 days of age

nervous system

abnormal hippocampus morphology ( J:146191 )

• Rosenthal fibers are observed, but numbers are significantly less than in Gfap^tm2Hgmn/+/Tg(GFAP)10Mes animals; both soluble and insoluble GFAP levels are reduced

Genotype
MGI:3850529

cx3

• Allelic Composition: Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr; Tg(GFAP)10Mes/0; Tg(GFAP-CRYAB)141.6Mes/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

mortality/aging

premature death ( J:146191 )

• majority of animals (about 90%) survive to 3 months of age

growth/size/body

growth/size/body region phenotype ( J:146191 )

N • mice show significantly increased body weights at 6 weeks and three months relative to Tg(GFAP)10Mes and Tg(GFAP)10/Tg(GFAP-Cryab)141.6Mes Cryab-null animals; weights are comparable to wild-type

nervous system

abnormal hippocampus morphology ( J:146191 )

• Rosenthal fibers which outline astrocytic processes are present in mutants

Genotype
MGI:3850534

cx4

• Allelic Composition: Gfap^tm2Mes/Gfap⁺; Tg(GFAP-CRYAB)141.6Mes/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB/N

cellular

abnormal cell physiology ( J:146191 )

• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfap^tm2Hgmn/+/+ mice

Genotype
MGI:3850535

cx5

• Allelic Composition: Tg(GFAP)10Mes/0; Tg(GFAP-CRYAB)141.6Mes/0
• Genetic Background: involves: FVB/N

cellular

abnormal cell physiology ( J:146191 )

• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfap^tm2Hgmn/+/+ mice