About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm4tm1.1Wahl
targeted mutation 1.1, Goeff Wahl
MGI:3850668
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm4tm1.1Wahl/Mdm4tm1.1Wahl involves: 129S/Sv * C57BL/6 MGI:3850670
cx2
 		Ightm1(Myc)Janz/Igh+
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl 		involves: 129S/Sv * C57BL/6 MGI:3850671


Genotype
MGI:3850670
hm1
Allelic
Composition		 Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic
Background		 involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm1.1Wahl mutation (0 available); any Mdm4 mutation (193 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased mortality induced by ionizing radiation ( J:150341 )
• only 60% of mice die following exposure to radiation that kills all wild-type mice

hematopoietic system
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells
increased erythrocyte cell number ( J:150341 )
• following irradiation, mice exhibit only moderate anemia compared to the severe anemia observed in similarly treated mice
thrombocytosis ( J:150341 )
• following irradiation, mice exhibit only moderate thrombocytopenia compared to the severe thrombocytopenia observed in similarly treated mice
increased leukocyte cell number ( J:150341 )
• following irradiation, mice exhibit only moderate leucopenia compared to the severe leucopenia observed in similarly treated mice

cellular
decreased cellular sensitivity to gamma-irradiation ( J:150341 )
• mouse embryonic fibroblasts exhibit resistance to gamma-radiation cell cycle arrest unlike wild-type cells
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells

neoplasm
neoplasm ( J:150341 )
N
• mice exhibit no obvious tumor predisposition

immune system
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells
increased leukocyte cell number ( J:150341 )
• following irradiation, mice exhibit only moderate leucopenia compared to the severe leucopenia observed in similarly treated mice

homeostasis/metabolism
decreased mortality induced by ionizing radiation ( J:150341 )
• only 60% of mice die following exposure to radiation that kills all wild-type mice

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells




Genotype
MGI:3850671
cx2
Allelic
Composition		 Ightm1(Myc)Janz/Igh+
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic
Background		 involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1(Myc)Janz mutation (2 available); any Igh mutation (44 available)
Mdm4tm1.1Wahl mutation (0 available); any Mdm4 mutation (193 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:150341 )
• mice exhibit increased premature lethality compared with Ightm1Janz heterozygotes

immune system

neoplasm
increased lymphoma incidence ( J:150341 )
• lymphomagenesis is accelerated compared to in Ightm1Janz heterozygotes

hematopoietic system

liver/biliary system

cellular

growth/size/body
enlarged liver ( J:150341 )
enlarged spleen ( J:150341 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory