Phenotypes associated with this allele

• Allele Symbol: Igh^{tm2.1(Tag)Rwhe}
• Allele Name: targeted mutation 2.1, Rudolf Hendriks
• Allele ID: MGI:3850723
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm2.1(Tag)Rwhe/Igh^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3850822
cx2	Igh^tm2.1(Tag)Rwhe/Igh^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3850823

Genotype
MGI:3850822

ht1

• Allelic Composition: Igh^{tm2.1(Tag)Rwhe}/Igh⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:150315 )

• the expansion of a monoclonal B cell population in these mice is indicative of leukemia

increased chronic lymphocytic leukemia incidence ( J:150315 )

immune system

enlarged spleen ( J:150315 )

• spleen size is increased with age due to the emergence of a monoclonal B cell population

abnormal B cell morphology ( J:150315 )

• as mice age, a large population emerges of monoclonal B cells preferentially expressing the wild-type allele

• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm

increased B cell number ( J:150315 )

• as mice age, the number of B cells in the blood increase due to the emergence of a monoclonal population

lymph node hyperplasia ( J:150315 )

• about 60% of mice with a monoclonal B cell population display lymph node hyperplasia with numbers being up to 15 fold higher

hematopoietic system

enlarged spleen ( J:150315 )

• spleen size is increased with age due to the emergence of a monoclonal B cell population

abnormal B cell morphology ( J:150315 )

• as mice age, a large population emerges of monoclonal B cells preferentially expressing the wild-type allele

• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm

increased B cell number ( J:150315 )

• as mice age, the number of B cells in the blood increase due to the emergence of a monoclonal population

growth/size/body

enlarged spleen ( J:150315 )

• spleen size is increased with age due to the emergence of a monoclonal B cell population

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:150315

Genotype
MGI:3850823

cx2

• Allelic Composition: Igh^{tm2.1(Tag)Rwhe}/Igh⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

neoplasm

increased leukemia incidence ( J:150315 )

• 5 of 6 mice develop B cell derived leukemia compared to Trp53 null controls that develop T cell lymphomas

• median tumor-free survival is 138 days compared to 161 in transgenic controls on a wild-type Trp53 background

increased chronic lymphocytic leukemia incidence ( J:150315 )