Analysis Tools
neoplasm
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• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice
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cellular
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• endothelial cell proliferation in response to VEGF is decreased compared to similarly treated wild-type cells
• DYRK1A suppression of VEGF-mediated endothelial proliferation is enhanced compared to in similarly treated wild-type cells
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cardiovascular system
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• endothelial cell proliferation in response to VEGF is decreased compared to similarly treated wild-type cells
• DYRK1A suppression of VEGF-mediated endothelial proliferation is enhanced compared to in similarly treated wild-type cells
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hematopoietic system
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• increase in megakaryocytes in hematopoietic tissues
• increase in mature CD41+ CD42+ megakaryocytes
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• megakaryocyte precursors show increased proliferation
• increase in bipotential megakaryocyte/erythroid progenitors
• decrease in committed megakaryocyte progenitors (an intermediate between the bipotential precursor and fully mature platelet)
• cell-cycle progression genes are upregulated in megakaryocyte progenitors suggesting rapid cycling through the committed megakaryocyte progenitor phase
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